2-Bromo-3-octylthiophene (CAS 145543-83-5)

2-Bromo-3-octylthiophene, often abbreviated as 2-Br-3-OT, is an aromatic compound hinged on a thiophene base with an attached branched alkyl side chain. This colorless liquid exhibits solubility in a majority of organic solvents and is characterized by low volatility. It acts as a critical component in the synthesis of a wide range of organic molecules and serves as a reagent in polymer synthesis. Furthermore, it is utilized as a foundational building block in nanomaterial production. Beyond these uses, 2-Bromo-3-octylthiophene has demonstrated potential biological activity in varying environments. Its utility extends to the synthesis of diverse organic molecules, including dyes, and it plays a vital role in the development of polymers and nanomaterials. The compound has demonstrated cytotoxic effects on various cell lines, including human breast and colon cancer cells. Studies also suggest that 2-Bromo-3-octylthiophene may inhibit the growth of certain bacterial strains like Staphylococcus aureus and Escherichia coli. However, the precise mechanism of action of 2-Bromo-3-octylthiophene remains an area of ongoing study. Preliminary research indicates that it may function as an inhibitor of specific enzymes, including topoisomerase I and DNA gyrase, and potentially restrict the activity of certain transcription factors, such as NF-κB.