2-Aminopurine Dihydrochloride (CAS 76124-64-6)
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2-Aminopurine Dihydrochloride is a purine analog that acts as a protein kinase inhibitor. The compound is a mutagen that can incorporate into DNA and has been used as a fluorescent probe. Studies indicate that it can alter checkpoints in the phases of the cell cycle, in particular alter cells to enter mitosis in S-phase arrested cells incorrectly and override a gamma radiation induced G2 block. Additionally, it has been demonstrated that 2-Aminopurine Dihydrochloride inhibits PITSLREbeta1 protein kinase activity, and that it can alter the structure and dynamics of DNA. 2-Aminopurine Dihydrochloride does not effect the protein kinase activity of p34cdc2. 2-Aminopurine Dihydrochloride is an inhibitor of PKR.
2-Aminopurine Dihydrochloride (CAS 76124-64-6) References
- 2-Aminopurine overrides multiple cell cycle checkpoints in BHK cells. | Andreassen, PR. and Margolis, RL. 1992. Proc Natl Acad Sci U S A. 89: 2272-6. PMID: 1549593
- The use of 2-aminopurine fluorescence to study DNA polymerase function. | Reha-Krantz, LJ. 2009. Methods Mol Biol. 521: 381-96. PMID: 19563118
- 2-Aminopurine incorporation perturbs the dynamics and structure of DNA. | Dallmann, A., et al. 2010. Angew Chem Int Ed Engl. 49: 5989-92. PMID: 20632340
- Studies on the pathway of incorporation of 2-aminopurine into the deoxyribonucleic acid of Escherichia coli. | Rogan, EG. and Bessman, MJ. 1970. J Bacteriol. 103: 622-33. PMID: 4919986
- The antimutagenic action of polyamines: suppression of the mutagenic action of an E. coli mutator gene and of 2-aminopurine. | Johnson, HG. and Bach, MK. 1966. Proc Natl Acad Sci U S A. 55: 1453-6. PMID: 5336284
- 2-Aminopurine overrides a late telophase delay created by ectopic expression of the PITSLRE beta 1 protein kinase. | Xiang, J., et al. 1994. Biochem Biophys Res Commun. 199: 1167-73. PMID: 8147857
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Aminopurine Dihydrochloride, 100 mg | sc-201524 | 100 mg | $73.00 | |||
2-Aminopurine Dihydrochloride, 500 mg | sc-201524A | 500 mg | $301.00 |