2-Amino-6-methylmercaptopurine (CAS 1198-47-6)

2-Amino-6-methylmercaptopurine is a synthetic purine derivative widely used in scientific and laboratory studies to mimic guanine, one of the natural bases in DNA and RNA. This compound is integral to investigations concerning the role of guanine in various biochemical and physiological processes, including how DNA sustains damage and the mechanisms behind its repair. Its utility extends to examining the broader implications of DNA mutations, gene expression, and the biological effects of altering guanine′s presence in cellular activities, such as cell growth, differentiation, and programmed cell death. The substance′s interaction with DNA and RNA—by substituting for guanine—leads to disruptions in normal cell functions, inducing DNA damage that might result in mutations and cellular irregularities. Through these mechanisms, 2-Amino-6-methylmercaptopurine contributes significantly to the field of genetic research, helping to elucidate the complex dynamics of cellular biology and the foundational aspects of genomics.