Date published: 2025-11-17

1-800-457-3801

SCBT Portrait Logo
Seach Input

2-Amino-4-(trifluoromethyl)benzoic acid (CAS 402-13-1)

0.0(0)
Write a reviewAsk a question

Alternate Names:
4-(Trifluoromethyl)anthranilic acid; 4-Carboxy-α,α,α-trifluoro-m-toluidine
CAS Number:
402-13-1
Molecular Weight:
205.13
Molecular Formula:
C8H6F3NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

2-Amino-4-(trifluoromethyl)benzoic acid, referred to as 2ATFB, belongs to the class of carboxylic acids and presents itself as a white crystalline solid that readily dissolves in water, ethanol, and other polar solvents. Its significance lies in being a intermediary in the synthesis of numerous pharmaceuticals and other organic compounds. As a versatile compound, 2-Amino-4-(trifluoromethyl)benzoic acid finds use in various applications, ranging from drug synthesis to analytical chemistry. In scientific research, 2-Amino-4-(trifluoromethyl)benzoic acid has proven indispensable in the creation of novel drugs and the development of analytical methods. One of the notable features of 2-Amino-4-(trifluoromethyl)benzoic acid is its role as a proton donor in the reaction between carboxylic acids and amines. This reaction is facilitated by the presence of a base, pyridine. The outcome of this protonation process results in the formation of an amide bond, a pivotal step in the synthesis of various pharmaceuticals and organic compounds, further underscoring the compound′s importance in the field.


2-Amino-4-(trifluoromethyl)benzoic acid (CAS 402-13-1) References

  1. Pd-Catalyzed Ortho C-H Hydroxylation of Benzaldehydes Using a Transient Directing Group.  |  Chen, XY., et al. 2017. Org Lett. 19: 6280-6283. PMID: 29129077
  2. LC-MS/MS study of the degradation processes of nitisinone and its by-products.  |  Barchanska, H., et al. 2019. J Pharm Biomed Anal. 171: 15-21. PMID: 30959315
  3. Influence of nitisinone and its metabolites on l-tyrosine metabolism in a model system.  |  Płonka, J., et al. 2022. Chemosphere. 286: 131592. PMID: 34311397
  4. Transient Directing Group Strategy as a Unified Method for Site Selective Direct C4-H Halogenation of Indoles.  |  Kuang, G., et al. 2021. Org Lett. 23: 8402-8406. PMID: 34664971

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Amino-4-(trifluoromethyl)benzoic acid, 1 g

sc-282884B
1 g
$20.00

2-Amino-4-(trifluoromethyl)benzoic acid, 5 g

sc-282884
5 g
$31.00

2-Amino-4-(trifluoromethyl)benzoic acid, 25 g

sc-282884A
25 g
$122.00