Molecular structure of 2-Acetylindole, CAS Number: 4264-35-1
2-Acetylindole (CAS 4264-35-1)
Alternate Names:
1-(1H-Indol-2-yl)ethanone; Indol-2-yl Methyl Ketone
Application:
2-Acetylindole is an indole derivative used in synthesis of matrix metalloprotease inhibitors
CAS Number:
4264-35-1
Molecular Weight:
159.18
Molecular Formula:
C10H9NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Acetylindole is an indole reagent used to synthesize matrix metalloprotease inhibitors. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases which degrade extracellular matrix proteins and process bioactive molecules. These endopeptidases also have a role in cell proliferation, migration, angiogenesis, apoptosis and host defense. Generating these inhibitors are of great importance in the study of MMPs.
2-Acetylindole (CAS 4264-35-1) References
- Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. | Van Lint, P. and Libert, C. 2007. J Leukoc Biol. 82: 1375-81. PMID: 17709402
- The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. | Van Wart, HE. and Birkedal-Hansen, H. 1990. Proc Natl Acad Sci U S A. 87: 5578-82. PMID: 2164689
- Indoles from o-nitrostyrenes. Synthesis and reactions of 2-indolyl 4-piperidylmethyl ketone | Sundberg, R. J. 1968. The Journal of Organic Chemistry. 33(2): 487-490.
- Enantiospecific reduction of prochiral ketones of aromatic type to optically active alcohols in Nigrospora oryzae culture | Jarosz, B., & Siewiński, A. 1996. Journal of basic microbiology. 36(4): 245-253.
- A novel approach to highly substituted β‐carbolines via reductive ring transformation of 2‐acyl‐3‐isoxazolylindoles | Kamlah, A., & Bracher, F. 2020. European Journal of Organic Chemistry. 2020(18): 2708-2719.
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Acetylindole, 1 g | sc-206367 | 1 g | $360.00 |