Molecular structure of 2-Acetamidofluorene, CAS Number: 53-96-3
2-Acetamidofluorene (CAS 53-96-3)
Alternate Names:
N-(2-Fluorenyl)acetamide; N-Acetyl-2-aminofluorene
CAS Number:
53-96-3
Purity:
≥98%
Molecular Weight:
223.27
Molecular Formula:
C15H13NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
2-Acetamidofluorene also referred to as 2-acetylaminofluorobenzene, 2-acetylaminofluorobenzene-2-carboxylic acid, and 2-acetylaminofluorobenzene-2-carboxylic acid ester, stands as an aromatic amine extensively utilized in both research and industrial contexts. Its remarkable reactivity makes it a versatile tool for generating a diverse array of compounds.The pronounced reactivity of 2-Acetamidofluorene fosters interactions with a broad spectrum of compounds, including proteins, enzymes, and DNA. Through these interactions, novel compounds can be forged. Although the precise mechanism of 2-AAF′s action remains somewhat elusive, the prevailing notion centers on the creation of covalent bonds between the molecule and its target compound.
2-Acetamidofluorene (CAS 53-96-3) References
- The relationship of 2-acetamidofluorene mutagenicity in plate tests with its in vivo liver cell component distribution and its carcinogenic potential. | McGregor, D. 1975. Mutat Res. 30: 305-15. PMID: 1105163
- The metabolism of 2-acetamidofluorene in the guinea-pig. | URQUHART, ME. 1955. Br J Cancer. 9: 611-2. PMID: 13304221
- Anti-hepatoma effect of arsenic trioxide on experimental liver cancer induced by 2-acetamidofluorene in rats. | Tan, B., et al. 2005. World J Gastroenterol. 11: 5938-43. PMID: 16273603
- A metabolite of 2-acetamidofluorene. | Bielschowsky, F. 1945. Biochem J. 39: 287-9. PMID: 16747906
- Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. | Best, DH. and Coleman, WB. 2007. J Hepatol. 46: 1055-63. PMID: 17434228
- Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene. | Matboli, M., et al. 2019. J Cell Biochem. 120: 14946-14959. PMID: 31009125
- Metabolism of 2-acetamidofluorene in the steppe lemming. | Weisburger, JH., et al. 1965. Br J Cancer. 19: 581-8. PMID: 5833076
- 2-Acetamidofluorene and 3-methylcholanthrene: differences in binding to rat liver deoxyribonucleic acid in vivo. | Sporn, MB. and Dingman, CW. 1966. Nature. 210: 531-2. PMID: 5960519
- Metabolism and nucleic acid binding of 7-fluoro-2-acetamidofluorene in rats: oxidative defluorination and apparent dissociation from hepatocarcinogenesis of 8-(N-arylamide) guanine adducts on DNA. | Scribner, JD., et al. 1982. Chem Biol Interact. 40: 27-43. PMID: 6176341
- Activation of benzo(a)pyrene and 2-acetamidofluorene to mutagens by microsomal preparations from different animal species: role of cytochrome P-450 and P-448. | Ioannides, C., et al. 1981. Xenobiotica. 11: 701-8. PMID: 6275616
- In vitro activation of the promutagens 2-acetamidofluorene, cyclophosphamide and 7,12-dimethylbenzanthracene by constitutive ferret and rat hepatic S-9 fractions. | Frederick, KA. and Babish, JG. 1984. Toxicology. 31: 73-86. PMID: 6427977
- Use of 2-acetamidophenanthrene and 2-acetamidofluorene in investigations of mechanisms of hepatocarcinogenesis. | Scribner, JD., et al. 1983. Environ Health Perspect. 49: 81-6. PMID: 6832098
- Immuno-electron-microscopic studies on the subcellular distribution of rat liver epoxide hydrolase and the effect of phenobarbitone and 2-acetamidofluorene treatment. | Waechter, F., et al. 1982. Biochem J. 202: 677-86. PMID: 7046735
- Developmental aspects of 2-acetamidofluorene metabolism and mutagenic activation in the chick. | Haug, LT., et al. 1980. Xenobiotica. 10: 863-72. PMID: 7210699
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Acetamidofluorene, 5 g | sc-253064 | 5 g | $122.00 |