2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-D-galactose (CAS 3554-90-3)
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2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-D-galactose, also known as human blood group antigen Tf, is a glycoprotein present on various cell types throughout the human body. It plays a role in cell-cell communication, recognition, and several physiological processes. 2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-D-galactose is found in hydrolysates of blood group A,B,H, and forms an essential part of their antigenic determinants. It is also inherent in the structure of the brain gangliosides. The mechanism of action of TF antigen revolves around its binding to specific receptors, known as T-cell receptor (TCR) complexes, on the surface of T-cells. Upon binding, a cascade of biochemical reactions is initiated within the T-cell, leading to its activation. This activation is for the T-cell′s recognition and binding of antigenic peptides.
2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-D-galactose (CAS 3554-90-3) References
- Expression of the Thomsen-Friedenreich antigen and of its putative carrier protein mucin 1 in the human placenta and in trophoblast cells in vitro. | Jeschke, U., et al. 2002. Histochem Cell Biol. 117: 219-26. PMID: 11914919
- THREE NEW TRISACCHARIDES OBTAINED FROM HUMAN BLOOD-GROUP A, B, H AND LEA SUBSTANCES: POSSIBLE SUGAR SEQUENCES IN THE CARBOHYDRATE CHAINS. | REGE, VP., et al. 1963. Nature. 200: 532-4. PMID: 14082217
- THE GANGLIOSIDES. | SVENNERHOLM, L. 1964. J Lipid Res. 5: 145-55. PMID: 14174000
- Mass spectrometry analysis of IgA1 hinge region in patients with IgA nephropathy. | Gastaldi, D., et al. 2007. J Nephrol. 20: 689-95. PMID: 18046671
- Identification of lacto-N-Biose I phosphorylase from Vibrio vulnificus CMCP6. | Nakajima, M. and Kitaoka, M. 2008. Appl Environ Microbiol. 74: 6333-7. PMID: 18723650
- The diversity of O-linked glycans expressed during Drosophila melanogaster development reflects stage- and tissue-specific requirements for cell signaling. | Aoki, K., et al. 2008. J Biol Chem. 283: 30385-400. PMID: 18725413
- Expression of the tumor markers sialyl Lewis A, sialyl Lewis X, Lewis Y, Thomsen-Friedenreich antigen, galectin-1 and galectin-3 in human osteoblasts in vitro. | Tübel, J., et al. 2012. Anticancer Res. 32: 2159-64. PMID: 22593503
- The role of the Thomsen-Friedenreich antigen as a tumor-associated molecule. | Dippold, W., et al. 1990. Environ Health Perspect. 88: 255-7. PMID: 2272320
- Engineered Glycan-Binding Proteins for Recognition of the Thomsen-Friedenreich Antigen and Structurally Related Disaccharides. | Ward, EM., et al. 2023. ACS Chem Biol. 18: 70-80. PMID: 36525666
- Selective release of the disaccharide 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-D-galactose from epiglycanin by endo-N-acetyl-alpha-D-galactosaminidase. | Bhavanandan, VP. and Codington, JF. 1983. Carbohydr Res. 118: 81-9. PMID: 6311416
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-D-galactose, 5 mg | sc-220672 | 5 mg | $388.00 |