Date published: 2026-4-5

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2,6-Lutidine (CAS 108-48-5)

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CAS Number:
108-48-5
Molecular Weight:
107.15
Molecular Formula:
C7H9N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,6-Lutidine is an aromatic heterocyclic compound, demonstrating solubility in various organic solvents. This compound plays a role as an intermediate in the production of diverse dyes and other chemical substances. Moreover, it holds broad application in synthesizing other aromatic compounds, including 2,6-dihydropyridine and 2,6-dimethoxy-pyridine.


2,6-Lutidine (CAS 108-48-5) References

  1. Kilo-scale synthesis process for 2'-O-(2-methoxyethyl)-pyrimidine derivatives.  |  Ross, BS., et al. 2005. Nucleosides Nucleotides Nucleic Acids. 24: 815-8. PMID: 16248042
  2. A series of mononuclear quasi-two-coordinate copper(I) complexes employing a sterically demanding thiolate ligand.  |  Groysman, S. and Holm, RH. 2009. Inorg Chem. 48: 621-7. PMID: 19138143
  3. Micelles of a diblock copolymer of styrene and ethylene oxide in mixtures of 2,6-lutidine and water.  |  Tuzar, Z., et al. 2008. Langmuir. 24: 13863-5. PMID: 19360951
  4. Copper-catalyzed, aerobic oxidative cross-coupling of alkynes with arylboronic acids: remarkable selectivity in 2,6-lutidine media.  |  Yasukawa, T., et al. 2011. Org Biomol Chem. 9: 6208-10. PMID: 21808793
  5. Oxoammonium salt oxidations of alcohols in the presence of pyridine bases.  |  Bobbitt, JM., et al. 2014. J Org Chem. 79: 1055-67. PMID: 24386938
  6. Electrophilic Phosphonium Cation-Mediated Phosphane Oxide Reduction Using Oxalyl Chloride and Hydrogen.  |  Stepen, AJ., et al. 2018. Angew Chem Int Ed Engl. 57: 15253-15256. PMID: 30230149
  7. Bis(pentalene)dititanium chemistry: C-H, C-X and H-H bond activation.  |  Tsoureas, N., et al. 2018. Dalton Trans. 47: 14531-14539. PMID: 30252008
  8. Access to Stereodefined (E)-2-Silylallylboronates via Regioselective Chloroboration of Allenylsilanes.  |  Yang, Z., et al. 2019. Org Lett. 21: 9541-9544. PMID: 31713429
  9. Photochemical Conversion of Isoxazoles to 5-Hydroxyimidazolines.  |  Morita, T., et al. 2020. Org Lett. 22: 3460-3463. PMID: 32286839
  10. Mechanistic details of metal-free cyclization reaction of organophosphorus oxide with alkynes mediated by 2,6-lutidine and Tf2 O.  |  Tian, J., et al. 2020. J Comput Chem. 41: 1709-1717. PMID: 32323872
  11. Confined Water Molecules in Binary Mixtures of Water and 2,6-Lutidine Near Lower Solution Critical Temperature.  |  Korotkevich, AA. and Bakker, HJ. 2021. J Phys Chem B. 125: 287-296. PMID: 33370126
  12. Calcium-mediated C(sp3)-H Activation and Alkylation of Alkylpyridines.  |  Zheng, X., et al. 2021. Inorg Chem. 60: 5114-5121. PMID: 33728911
  13. Photoredox-catalyzed intramolecular cyclopropanation of alkenes with α-bromo-β-keto esters.  |  Ide, K., et al. 2021. Org Biomol Chem. 19: 9172-9176. PMID: 34664610
  14. Efficient Purification of 2,6-Lutidine by Nonporous Adaptive Crystals of Pillararenes.  |  Wang, Z., et al. 2022. ACS Appl Mater Interfaces. 14: 41072-41078. PMID: 36053117
  15. Synthesis of β,β-Disubstituted Styrenes via Trimethylsilyl Trifluoromethanesulfonate-Promoted Aldehyde-Aldehyde Aldol Coupling-Elimination.  |  Dixon, GJ., et al. 2022. J Org Chem. 87: 14846-14854. PMID: 36239694

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,6-Lutidine, 25 ml

sc-238428
25 ml
$89.00