2,6-Bis[(4S)-(−)-isopropyl-2-oxazolin-2-yl]pyridine (CAS 118949-61-4)

2,6-Bis[(4S)-(−)-isopropyl-2-oxazolin-2-yl]pyridine, registered under the CAS number 118949-61-4, is a chiral ligand that has garnered attention in the field of synthetic chemistry for its application in asymmetric catalysis. This chemical features a pyridine ring substituted at the 2 and 6 positions with (4S)-(−)-isopropyl-2-oxazolin-2-yl groups, which confer chirality and enhance the ligand′s ability to induce enantioselectivity in various chemical reactions. The structure of this compound allows it to form stable complexes with transition metals, which are crucial for catalyzing reactions that involve the formation of asymmetric centers, thereby facilitating the synthesis of chiral molecules. These metal-ligand complexes are particularly useful in reactions such as hydrogenation, hydrosilylation, and carbon-carbon bond-forming reactions, where control over stereochemistry is critical. In research, 2,6-Bis[(4S)-(−)-isopropyl-2-oxazolin-2-yl]pyridine is employed to study the mechanisms through which chiral catalysts operate and to develop new catalytic systems that can achieve higher selectivity and activity. By understanding how different substituents on the ligand and variations in reaction conditions affect catalytic outcomes, researchers can design more efficient and selective processes for the synthesis of optically active compounds, contributing significantly to advancements in the field of organic synthesis and material science.