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2,5-Dihydroxybenzoic acid (CAS 490-79-9)

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Alternate Names:
Gentisic acid
CAS Number:
490-79-9
Molecular Weight:
154.12
Molecular Formula:
C7H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,5-Dihydroxybenzoic acid functions as a chelating agent in various experimental applications. It is capable of forming stable complexes with metal ions, particularly iron and copper, through the coordination of its hydroxyl groups. 2,5-Dihydroxybenzoic Acid′s mechanism of action involves the formation of coordination bonds with metal ions, leading to the sequestration and stabilization of these ions in solution. This chelating property allows 2,5-dihydroxybenzoic acid to be utilized in the isolation and purification of metal ions from complex mixtures, as well as in the determination of metal ion concentrations in analytical chemistry. 2,5-Dihydroxybenzoic acid can also serve as a reducing agent, participating in redox reactions with metal ions to form colored complexes that are useful in spectrophotometric assays. 2,5-dihydroxybenzoic acid plays a functional role in experimental applications by facilitating the chelation and detection of metal ions.


2,5-Dihydroxybenzoic acid (CAS 490-79-9) References

  1. 2,5-Dihydroxybenzoic acid butylamine and other ionic liquid matrixes for enhanced MALDI-MS analysis of biomolecules.  |  Mank, M., et al. 2004. Anal Chem. 76: 2938-50. PMID: 15144208
  2. Assessment of antioxidant effect of 2,5-dihydroxybenzoic acid and vitamin a in brains of rats with induced hyperoxia.  |  Calderón Guzmán, D., et al. 2007. Neurochem Res. 32: 1036-40. PMID: 17401673
  3. A 2,5-dihydroxybenzoic acid/N,N-dimethylaniline matrix for the analysis of oligosaccharides by matrix-assisted laser desorption/ionization mass spectrometry.  |  Snovida, SI. and Perreault, H. 2007. Rapid Commun Mass Spectrom. 21: 3711-5. PMID: 17952888
  4. Mechanistic study of electrochemical oxidation of 2,5-dihydroxybenzoic acid and 3,4-dihydroxybenzaldehyde in the presence of 3-hydroxy-1H-phenalene-1-one.  |  Nematollahi, D. and Amani, A. 2008. Chem Pharm Bull (Tokyo). 56: 513-7. PMID: 18379100
  5. Comparative acute nephrotoxicity of salicylic acid, 2,3-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid in young and middle aged Fischer 344 rats.  |  McMahon, TF., et al. 1991. Toxicology. 66: 297-311. PMID: 2011854
  6. Does decarboxylation make 2,5-dihydroxybenzoic acid special in matrix-assisted laser desorption/ionization?  |  Hsu, HC., et al. 2014. Rapid Commun Mass Spectrom. 28: 1082-8. PMID: 24711271
  7. Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice.  |  Liu, Z., et al. 2014. Mol Cell Biol. 34: 2533-46. PMID: 24777603
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  10. Magnetic core-shell iron(II,III) oxide@layered double oxide microspheres for removal of 2,5-dihydroxybenzoic acid from aqueous solutions.  |  Tang, S., et al. 2015. J Colloid Interface Sci. 437: 316-323. PMID: 25441367
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  12. A 2,5-Dihydroxybenzoic Acid-Gelatin Conjugate: The Synthesis, Antiviral Activity and Mechanism of Antiviral Action Against Two Alphaherpesviruses.  |  Lisov, A., et al. 2015. Viruses. 7: 5343-60. PMID: 26501311
  13. S5H/DMR6 Encodes a Salicylic Acid 5-Hydroxylase That Fine-Tunes Salicylic Acid Homeostasis.  |  Zhang, Y., et al. 2017. Plant Physiol. 175: 1082-1093. PMID: 28899963
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,5-Dihydroxybenzoic acid, 10 mg

sc-251860
10 mg
$20.00

2,5-Dihydroxybenzoic acid, 100 mg

sc-251860A
100 mg
$157.00