Date published: 2026-4-25

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2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic acid (CAS 487-66-1)

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Alternate Names:
2-(2-Carboxyethyl)-3-methylmaleic
CAS Number:
487-66-1
Molecular Weight:
184.15
Molecular Formula:
C8H8O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid exhibits diverse biochemical effects. It has been observed to possess inhibitory properties against enzymes responsible for generating inflammatory mediators, including cyclooxygenase-2. Furthermore, it demonstrates antioxidant activity by reducing the formation of reactive oxygen species.


2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic acid (CAS 487-66-1) References

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  2. Codelivery of Anti-PD-1 Antibody and Paclitaxel with Matrix Metalloproteinase and pH Dual-Sensitive Micelles for Enhanced Tumor Chemoimmunotherapy.  |  Su, Z., et al. 2020. Small. 16: e1906832. PMID: 31990457
  3. Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death.  |  Zheng, P., et al. 2021. Nano Lett. 21: 2088-2093. PMID: 33596078
  4. Dual-Sensitive PEG-Sheddable Nanodrug Hierarchically Incorporating PD-L1 Antibody and Zinc Phthalocyanine for Improved Immuno-Photodynamic Therapy.  |  Su, Z., et al. 2021. ACS Appl Mater Interfaces. 13: 12845-12856. PMID: 33709684
  5. A tumor extracellular pH-sensitive PD-L1 binding peptide nanoparticle for chemo-immunotherapy of cancer.  |  Zhu, W., et al. 2021. J Mater Chem B. 9: 4201-4210. PMID: 33997867
  6. Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy.  |  Wang, K., et al. 2022. ACS Nano. 16: 721-735. PMID: 34978422
  7. Spatial specific delivery of combinational chemotherapeutics to combat intratumoral heterogeneity.  |  Wang, K., et al. 2022. J Control Release. 348: 1004-1015. PMID: 35779654
  8. Co-delivery of proanthocyanidin and mitoxantrone induces synergistic immunogenic cell death to potentiate cancer immunotherapy.  |  Qian, Y., et al. 2022. Biomater Sci. 10: 4549-4560. PMID: 35790120
  9. Inflammation-Regulated Nanodrug Sensitizes Hepatocellular Carcinoma to Checkpoint Blockade Therapy by Reprogramming the Tumor Microenvironment.  |  Wang, T., et al. 2022. ACS Appl Mater Interfaces.. PMID: 36314479
  10. Probiotic Escherichia coli Nissle 1917 propelled micro-robot with pH sensitivity for hypoxia targeted intestinal tumor therapy.  |  Wang, T., et al. 2023. Colloids Surf B Biointerfaces. 225: 113277. PMID: 36996630

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic acid, 1 g

sc-489785
1 g
$235.00