Molecular structure of 2,5-Anhydro-D-mannitol, CAS Number: 41107-82-8
2,5-Anhydro-D-mannitol (CAS 41107-82-8)
See product citations (4)
Application:
2,5-Anhydro-D-mannitol is a carbohydrate metabolism regulator
CAS Number:
41107-82-8
Molecular Weight:
164.16
Molecular Formula:
C6H12O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2,5-Anhydro-D-mannitol is a carbohydrate metabolism regulator that may act to inhibit gluconeogenesis from lactate plus pyruvate and from substrates that enter the gluconeogenic pathway as triose phosphate. It is a sugar alcohol that is readily absorbed from the gastrointestinal tract. It is metabolized in the liver by the enzyme aldose reductase to form 2,5-anhydro-D-mannitol-1-phosphate, which is then converted to D-mannitol-1-phosphate. This compound is then further metabolized to form D-mannitol, which is then excreted in the urine. 2,5-Anhydro-D-mannitol has been used as a model compound for the study of sugar alcohol metabolism, as a substrate for the study of enzyme kinetics, and as a tool for the study of carbohydrate-protein interactions.
2,5-Anhydro-D-mannitol (CAS 41107-82-8) References
- 2,5-Anhydro-D-mannitol increases hepatocyte calcium: implications for a hepatic hunger stimulus. | Rawson, NE., et al. 2003. Biochim Biophys Acta. 1642: 59-66. PMID: 12972294
- Synthesis of anticoagulantly active heparan sulfate proteoglycans by glomerular epithelial cells involves multiple 3-O-sulfotransferase isoforms and a limiting precursor pool. | Girardin, EP., et al. 2005. J Biol Chem. 280: 38059-70. PMID: 16107334
- Effect of a nonmetabolizable analog of fructose-1,6-bisphosphate on glycolysis and ethanol production in strains of Saccharomyces cerevisiae and Escherichia coli. | Nghiem, NP. and Cofer, TM. 2007. Appl Biochem Biotechnol. 141: 335-47. PMID: 18025560
- 2,5-anhydro-D-mannitol acts in liver to initiate feeding. | Tordoff, MG., et al. 1991. Am J Physiol. 261: R283-8. PMID: 1908642
- SLC2A5 promotes lung adenocarcinoma cell growth and metastasis by enhancing fructose utilization. | Weng, Y., et al. 2018. Cell Death Discov. 4: 38. PMID: 29531835
- 2,5-anhydro-D-mannitol: a fructose analogue that increases food intake in rats. | Tordoff, MG., et al. 1988. Am J Physiol. 254: R150-3. PMID: 3122594
- Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs. | Rana, N., et al. 2022. Pharmaceutics. 14: PMID: 35456662
- The PICLS high-throughput screening method for agents extending cellular longevity identifies 2,5-anhydro-D-mannitol as novel anti-aging compound. | Alfatah, M. and Eisenhaber, F. 2023. Geroscience. 45: 141-158. PMID: 35705837
- Inhibition of gluconeogenesis by 2,5-anhydro-D-mannitol in isolated rat hepatocytes. | Stevens, HC., et al. 1985. Biochim Biophys Acta. 845: 502-6. PMID: 3924119
- Mechanism of action of 2,5-anhydro-D-mannitol in hepatocytes. Effects of phosphorylated metabolites on enzymes of carbohydrate metabolism. | Riquelme, PT., et al. 1984. J Biol Chem. 259: 5115-23. PMID: 6325420
- Inhibition of gluconeogenesis and glycogenolysis by 2,5-anhydro-D-mannitol. | Hanson, RL., et al. 1984. J Biol Chem. 259: 218-23. PMID: 6423625
- Effects of GLP-1 and 2,5-anhydro-D-mannitol on insulin secretion and plasma glucose in mice. | Ahrén, B., et al. 1995. Endocr Res. 21: 583-94. PMID: 7588428
- Phosphate loading prevents the decrease in ATP and increase in food intake produced by 2,5-anhydro-D-mannitol. | Rawson, NE. and Friedman, MI. 1994. Am J Physiol. 266: R1792-6. PMID: 8024030
- Induction of Fos-like immunoreactivity (Fos-li) and stimulation of feeding by 2,5-anhydro-D-mannitol (2,5-AM) require the vagus nerve. | Ritter, S., et al. 1994. Brain Res. 646: 53-64. PMID: 8055341
- Hepatic phosphate trapping, decreased ATP, and increased feeding after 2,5-anhydro-D-mannitol. | Rawson, NE., et al. 1994. Am J Physiol. 266: R112-7. PMID: 8304531
- Intraportal infusion of 2,5-anhydro-D-mannitol increases afferent activity in the common hepatic vagus branch. | Lutz, TA., et al. 1996. J Auton Nerv Syst. 61: 204-8. PMID: 8946344
- 2,5-Anhydro-D-mannitol induces Fos-like immunoreactivity in hindbrain and forebrain: relationship to eating behavior. | Horn, CC. and Friedman, MI. 1998. Brain Res. 779: 17-25. PMID: 9473567
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,5-Anhydro-D-mannitol, 10 mg | sc-220807A | 10 mg | $130.00 | |||
2,5-Anhydro-D-mannitol, 100 mg | sc-220807 | 100 mg | $377.00 |