Date published: 2025-10-31

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2-(4-methylpiperazin-1-yl)ethanamine (CAS 934-98-5)

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CAS Number:
934-98-5
Molecular Weight:
143.23
Molecular Formula:
C7H17N3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-(4-Methylpiperazin-1-yl)ethanamine, a derivative of the piperazine family, represents a fundamental structure in the exploration of chemical biology, particularly in the domain of neurotransmitter receptor modulation. Its structural framework is conducive to engaging with a variety of receptor sites, thereby serving as a pivotal scaffold in the synthesis of compounds aimed at elucidating receptor function and signal transduction mechanisms within neurological pathways. The inclusion of the methyl group on the piperazine ring enhances lipophilicity, potentially affecting the compound′s interaction with biological membranes and receptor sites, thus making it a versatile tool in the study of receptor-ligand interactions. By facilitating the synthesis of analogs with varied affinities and selectivities for different receptor types, 2-(4-Methylpiperazin-1-yl)ethanamine aids in the dissection of complex signaling pathways, contributing to a deeper understanding of molecular pharmacology devoid of any direct application to clinical or therapeutic contexts. Its utility in research extends to serving as a chemical precursor in the development of more complex molecules designed to probe the physiological roles and therapeutic potential of neurotransmitter systems, thereby underlining its importance in the foundational aspects of neurochemical research.


2-(4-methylpiperazin-1-yl)ethanamine (CAS 934-98-5) References

  1. Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds.  |  Eberle, C., et al. 2009. ChemMedChem. 4: 2034-44. PMID: 19847846
  2. Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents.  |  Zuo, SJ., et al. 2016. Bioorg Med Chem. 24: 179-90. PMID: 26706113
  3. Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.  |  Gilson, PR., et al. 2017. J Med Chem. 60: 1171-1188. PMID: 28080063
  4. Structure-activity relationship studies on divalent naphthalene diimide G quadruplex ligands with anticancer and antiparasitic activity.  |  Pérez-Soto, M., et al. 2022. Bioorg Med Chem. 71: 116946. PMID: 35939903

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-(4-methylpiperazin-1-yl)ethanamine, 1 g

sc-273905
1 g
$214.00