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2,4-Dihydroxybenzoic acid (CAS 89-86-1)

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Alternate Names:
β-Resorcylic acid
Application:
2,4-Dihydroxybenzoic acid is a organic building block
CAS Number:
89-86-1
Molecular Weight:
154.12
Molecular Formula:
C7H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,4-Dihydroxybenzoic acid (2,4-DHB) emerges naturally as a phenolic acid present in numerous plant species. It serves as an intermediate in synthesizing other compounds and exhibits relevance in the fields of biochemistry and pharmacology. The precise mechanism of action for 2,4-Dihydroxybenzoic acid remains incompletely understood. Nonetheless, it is believed that this compound may exert its effects by modulating the activity of diverse enzymes, binding to specific receptors, or inhibiting the activity of particular enzymes.


2,4-Dihydroxybenzoic acid (CAS 89-86-1) References

  1. Absorption spectra of radical forms of 2,4-dihydroxybenzoic acid, a substrate for p-hydroxybenzoate hydroxylase.  |  Anderson, RF., et al. 1991. J Biol Chem. 266: 13086-90. PMID: 1649177
  2. Structure and hydrogen bonding in 2,4-dihydroxybenzoic acid at 90, 100, 110 and 150 K; a theoretical and single-crystal X-ray diffraction study.  |  Parkin, A., et al. 2007. Acta Crystallogr B. 63: 303-8. PMID: 17374941
  3. A study of oleic acid and 2,4-DHB acid aerosols using an IR-VUV-ITMS: insights into the strengths and weaknesses of the technique.  |  Hanna, SJ., et al. 2009. Phys Chem Chem Phys. 11: 7963-75. PMID: 19727503
  4. Novel pathway for the degradation of 2-chloro-4-nitrobenzoic acid by Acinetobacter sp. strain RKJ12.  |  Prakash, D., et al. 2011. Appl Environ Microbiol. 77: 6606-13. PMID: 21803909
  5. Degradation of 2,4-dihydroxibenzoic acid by vacuum UV process in aqueous solution: kinetic, identification of intermediates and reaction pathway.  |  Azrague, K., et al. 2012. J Hazard Mater. 237-238: 71-8. PMID: 22975258
  6. A combined experimental and theoretical analysis on molecular structure and vibrational spectra of 2,4-dihydroxybenzoic acid.  |  Tao, Y., et al. 2015. Spectrochim Acta A Mol Biomol Spectrosc. 137: 1078-85. PMID: 25300039
  7. Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.  |  Fueyo González, FJ., et al. 2017. J Med Chem. 60: 1509-1522. PMID: 28112515
  8. Electrostatic properties of the pyrimethamine-2,4-dihydroxybenzoic acid cocrystal in methanol studied using transferred electron-density parameters.  |  Faroque, MU., et al. 2018. Acta Crystallogr C Struct Chem. 74: 100-107. PMID: 29303503
  9. Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice.  |  Widmeier, E., et al. 2019. J Am Soc Nephrol. 30: 393-405. PMID: 30737270
  10. Potential of 2,4-Dihydroxybenzoic Acid as an Oviposition Stimulant for Mass-Reared Ladybird Beetles.  |  Riddick, EW., et al. 2019. J Insect Sci. 19: PMID: 30822780
  11. ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment.  |  Widmeier, E., et al. 2020. J Am Soc Nephrol. 31: 1191-1211. PMID: 32381600
  12. Beta resorcylic acid lactones (RALs) from fungi: chemistry, biology, and biosynthesis.  |  Bang, S. and Shim, SH. 2020. Arch Pharm Res. 43: 1093-1113. PMID: 33113097
  13. Natural resorcylic acid lactones: A chemical biology approach for anticancer activity.  |  Kuttikrishnan, S., et al. 2022. Drug Discov Today. 27: 547-557. PMID: 34655796
  14. Hypouricemic effect of 2,4-dihydroxybenzoic acid methyl ester in hyperuricemic mice through inhibiting XOD and down-regulating URAT1.  |  Yong, T., et al. 2022. Biomed Pharmacother. 153: 113303. PMID: 35750011

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,4-Dihydroxybenzoic acid, 5 g

sc-238335
5 g
$51.00

2,4-Dihydroxybenzoic acid, 100 g

sc-238335A
100 g
$56.00