Date published: 2026-4-25

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2,4-Dichloro-5-(trifluoromethyl)pyrimidine (CAS 3932-97-6)

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CAS Number:
3932-97-6
Molecular Weight:
216.98
Molecular Formula:
C5HCl2F3N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,4-Dichloro-5-(trifluoromethyl)pyrimidine is classified as a halogenated organic compound. In the field of organic synthesis, it serves as a fundamental building block for synthesizing a wide array of other organic compounds. Additionally, in environmental science, it has been utilized to explore the effects of halogenated compounds on the environment. While the precise mechanism of action of it remains incompletely understood, it is hypothesized to involve the formation of a covalent bond between the halogen atoms of it and the target molecule. This covalent bond subsequently leads to alterations in the properties of the target molecule, such as changes in reactivity or solubility.


2,4-Dichloro-5-(trifluoromethyl)pyrimidine (CAS 3932-97-6) References

  1. 2-Chloro-4-(1H-pyrazol-1-yl)-5-(trifluoro-meth-yl)pyrimidine.  |  Bunker, KD., et al. 2010. Acta Crystallogr Sect E Struct Rep Online. 66: o1448. PMID: 21579519
  2. Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease.  |  Chen, Z., et al. 2019. ChemMedChem. 14: 1580-1585. PMID: 31365783
  3. PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo.  |  Li, F., et al. 2020. Acta Pharm Sin B. 10: 289-300. PMID: 32082974
  4. Synthesis and Fundamental Evaluation of Radioiodinated Rociletinib (CO-1686) as a Probe to Lung Cancer with L858R/T790M Mutations of Epidermal Growth Factor Receptor (EGFR).  |  Fawwaz, M., et al. 2020. Molecules. 25: PMID: 32599930
  5. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs.  |  Gao, H., et al. 2020. ACS Med Chem Lett. 11: 1855-1862. PMID: 33062164
  6. The tale of proteolysis targeting chimeras (PROTACs) for Leucine-Rich Repeat Kinase 2 (LRRK2).  |  Konstantinidou, M., et al. 2021. ChemMedChem. 16: 959-965. PMID: 33278061
  7. A Radiobrominated Tyrosine Kinase Inhibitor for EGFR with L858R/T790M Mutations in Lung Carcinoma.  |  Fawwaz, M., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 33809064
  8. Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors.  |  Yan, L., et al. 2022. J Enzyme Inhib Med Chem. 37: 832-843. PMID: 35260020
  9. Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs.  |  Qin, Q., et al. 2022. J Enzyme Inhib Med Chem. 37: 2241-2255. PMID: 35978496

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,4-Dichloro-5-(trifluoromethyl)pyrimidine, 250 mg

sc-254331
250 mg
$81.00