Date published: 2025-11-16

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2,4,6-Tri-tert-butylpyridine (CAS 20336-15-6)

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Application:
2,4,6-Tri-tert-butylpyridine is used in indole triflones synthesis
CAS Number:
20336-15-6
Purity:
99%
Molecular Weight:
247.42
Molecular Formula:
C17H29N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,4,6-Tri-tert-butylpyridine is a chemical compound that is studied extensively in the field of organic chemistry due to its sterically hindered structure. It serves as a ligand in coordination chemistry, where researchers explore its ability to bind to transition metals and influence the reactivity and stability of metal complexes. This property is for catalysis studies, particularly in reactions where bulky ligands can promote selectivity or prevent unwanted side reactions. In materials science, 2,4,6-Tri-tert-butylpyridine is of interest for its potential use in the design of new organic materials with specific electronic properties. Additionally, the steric hindrance provided by the tert-butyl groups makes it a useful reagent in probing the mechanisms of reactions that are sensitive to the spatial arrangement of atoms and groups within a molecule. This compound also plays a role in supramolecular chemistry, where it can be used to investigate the principles of molecular recognition and assembly.


2,4,6-Tri-tert-butylpyridine (CAS 20336-15-6) References

  1. Changing the ortho/para ratio in aromatic acylation reactions by changing reaction conditions: a mechanistic explanation from kinetic measurements.  |  Effenberger, F. and Maier, AH. 2001. J Am Chem Soc. 123: 3429-33. PMID: 11472113
  2. Synthesis of indole and biindolyl triflones: trifluoromethanesulfonylation of indoles with Tf2O/TTBP (2,4,6-tri-tert-butylpyridine) system.  |  Xu, XH., et al. 2011. Org Lett. 13: 4854-7. PMID: 21848305
  3. Sterically Hindered 2,4,6-Tri- tert-butylpyridinium Salts as Single Hydrogen Bond Donors for Highly Stereoselective Glycosylation Reactions of Glycals.  |  Ghosh, T., et al. 2019. Org Lett. 21: 3490-3495. PMID: 31050439
  4. C-H···Anion Interactions Assisted Addition of Water to Glycals by Sterically Hindered 2,4,6-Tri-tert-butylpyridinium Hydrochloride.  |  Mukherji, A. and Kancharla, PK. 2020. Org Lett. 22: 2191-2195. PMID: 32115959
  5. Probing the Brønsted Acidity of the External Surface of Faujasite-Type Zeolites.  |  Lakiss, L., et al. 2020. Chemphyschem. 21: 1873-1881. PMID: 32176421
  6. Sterically Strained Brønsted Pair Catalysis by Bulky Pyridinium Salts: Direct Stereoselective Synthesis of 2-Deoxy and 2,6-Dideoxy-β-thioglycosides from Glycals.  |  Mukherji, A., et al. 2021. J Org Chem. 86: 17226-17243. PMID: 34794312
  7. TfO-···H-O-H Interaction-Assisted Generation of a Silicon Cation from Allylsilanes: Access to Phenylallyl Ferrier Glycosides from Glycals.  |  Addanki, RB., et al. 2022. Org Lett. 24: 1465-1470. PMID: 35142527
  8. Oxidation of Iodine to Dihaloiodate(I) Salts of Amines With Hydrogen Peroxides and Their Crystal Structures.  |  Prinčič, GG., et al. 2022. Front Chem. 10: 912383. PMID: 35601560

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,4,6-Tri-tert-butylpyridine, 1 g

sc-225709
1 g
$87.00

2,4,6-Tri-tert-butylpyridine, 5 g

sc-225709A
5 g
$296.00