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2,4,4-Trimethyl-2-pentanol (CAS 690-37-9)

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Alternate Names:
2-Hydroxy-2,4,4-trimethylpentane
CAS Number:
690-37-9
Molecular Weight:
130.23
Molecular Formula:
C8H18O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,4,4-Trimethyl-2-pentanol is a compound that researchers in the field of synthetic organic chemistry and materials science find useful due to its unique structural properties. As an alcohol with a branched structure, it is often examined for its reactivity in various chemical transformations, such as esterification and etherification reactions, which are fundamental in synthesizing a wide array of chemical products. Additionally, 2,4,4-Trimethyl-2-pentanol is employed in the study of hydrophobic polymers where its incorporation can influence the water resistance and mechanical properties of the materials. It also serves as a model compound for understanding the steric effects of bulky groups in organic reactions, which is for designing molecules with desired reactivity patterns. Furthermore, due to its tertiary alcohol structure, it provides insight into the stability of carbocations formed during organic synthesis and the potential for rearrangements.


2,4,4-Trimethyl-2-pentanol (CAS 690-37-9) References

  1. A physiological model for ligand-induced accumulation of alpha 2u globulin in male rat kidney: roles of protein synthesis and lysosomal degradation in the renal dosimetry of 2,4,4-trimethyl-2-pentanol.  |  Kohn, MC. and Melnick, RL. 1999. Toxicology. 136: 89-105. PMID: 10514002
  2. Formation of the metabolic intermediate 2,4,4-trimethyl-2-pentanol during incubation of a Sphingomonas sp. strain with the xeno-estrogenic octylphenol.  |  Tanghe, T., et al. 2000. Biodegradation. 11: 11-9. PMID: 11194969
  3. Use of sensitivity analysis to assess reliability of metabolic and physiological models.  |  Kohn, MC. 2002. Risk Anal. 22: 623-31. PMID: 12088237
  4. Alpha 2u-globulin is the only member of the lipocalin protein superfamily that binds to hyaline droplet inducing agents.  |  Lehman-McKeeman, LD. and Caudill, D. 1992. Toxicol Appl Pharmacol. 116: 170-6. PMID: 1384170
  5. Characteristics of chemical binding to alpha 2u-globulin in vitro--evaluating structure-activity relationships.  |  Borghoff, SJ., et al. 1991. Toxicol Appl Pharmacol. 107: 228-38. PMID: 1704644
  6. Identification of opdA, a gene involved in biodegradation of the endocrine disrupter octylphenol.  |  Porter, AW. and Hay, AG. 2007. Appl Environ Microbiol. 73: 7373-9. PMID: 17890335
  7. Solution focused nursing: a fitting model for mental health nurses working in a public health paradigm.  |  McAllister, M. 2010. Contemp Nurse. 34: 149-57. PMID: 20509799
  8. 2,2,4-Trimethylpentane-induced nephrotoxicity. I. Metabolic disposition of TMP in male and female Fischer 344 rats.  |  Charbonneau, M., et al. 1987. Toxicol Appl Pharmacol. 91: 171-81. PMID: 2445050
  9. Involvement of reversible binding to alpha 2u-globulin in 1,4-dichlorobenzene-induced nephrotoxicity.  |  Charbonneau, M., et al. 1989. Toxicol Appl Pharmacol. 99: 122-32. PMID: 2471290
  10. Identification of urinary metabolites of the nephrotoxic hydrocarbon 2,2,4-trimethylpentane in male rats.  |  Olson, CT., et al. 1985. Biochem Biophys Res Commun. 130: 313-6. PMID: 4026835
  11. Development of a mechanism-based dosimetry model for 2,4,4-trimethyl-2-pentanol-induced alpha 2u-globulin nephropathy in male Fischer 344 rats.  |  Borghoff, SJ., et al. 1995. Fundam Appl Toxicol. 25: 124-37. PMID: 7541379
  12. Assessment of binding of 2,4,4-trimethyl-2-pentanol to low-molecular-weight proteins isolated from kidneys of male rats and humans.  |  Borghoff, SJ. and Lagarde, WH. 1993. Toxicol Appl Pharmacol. 119: 228-35. PMID: 7683150
  13. Weight of evidence versus weight of speculation to evaluate the alpha2u-globulin hypothesis.  |  Melnick, RL., et al. 1997. Environ Health Perspect. 105: 904-6. PMID: 9341100

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,4,4-Trimethyl-2-pentanol, 1 g

sc-475564
1 g
$206.00