Molecular structure of 2-((3-Trifluoromethyl)phenyl)histamine dimaleate, CAS Number: 162049-83-4
2-((3-Trifluoromethyl)phenyl)histamine dimaleate (CAS 162049-83-4)
Alternate Names:
Compound 39
Application:
2-((3-Trifluoromethyl)phenyl)histamine dimaleate is an extremely potent and selective H1 receptor agonist
CAS Number:
162049-83-4
Purity:
≥98%
Molecular Weight:
487.38
Molecular Formula:
C20H20F3N3O8
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Found to be the most potent and selective H1 histamine receptor agonist of a panel of compounds in functional in vitro studies on histamine H2, H3, and other neurotransmitter receptors. It showed better potency at the guinea pig H1 histamine receptor than at the human H1 histamine receptor (pKi : 5.9). The selectivity of 2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be 2138 (H1:H2), > 64 (H1:H3), 1000 (H1:M3), 105 (H1: a1), 708 (H1:β1), and 71 (H1:5HT2A). This substance does not cross the blood-brain barrier.
2-((3-Trifluoromethyl)phenyl)histamine dimaleate (CAS 162049-83-4) References
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- Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis. | Lu, C., et al. 2010. Proc Natl Acad Sci U S A. 107: 18967-72. PMID: 20956310
- NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells. | Esposito, B., et al. 2011. Blood. 117: 4968-77. PMID: 21364192
- Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion. | Hayashi, D., et al. 2012. Invest Ophthalmol Vis Sci. 53: 2993-3003. PMID: 22467574
- Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells. | Li, D., et al. 2012. Invest Ophthalmol Vis Sci. 53: 6928-38. PMID: 22956601
- Cyclic ADP-Ribose and NAADP in Vascular Regulation and Diseases. | Li, PL., et al. 2013. Messenger (Los Angel). 2: 63-85. PMID: 24749015
- Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells. | He, M., et al. 2018. Invest Ophthalmol Vis Sci. 59: 3543-3553. PMID: 30025103
- The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review. | Zhou, R., et al. 2022. Front Neurosci. 16: 947295. PMID: 36188456
Activator of:
Histamine H1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-((3-Trifluoromethyl)phenyl)histamine dimaleate, 5 mg | sc-251656 | 5 mg | $99.00 |