Molecular structure of 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid, CAS Number: 64054-40-6
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid (CAS 64054-40-6)
Application:
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is an analog of PGE2
CAS Number:
64054-40-6
Purity:
≥96%
Molecular Weight:
341.5
Molecular Formula:
C19H35NO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that plays important roles in bone formation and resorption (1), cancer (2) and atherosclerosis (3) by elevating the second messenger cAMP. This chemical is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively) (4). This chemical stimulates cAMP formation in excised murine ovaries (5).
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid (CAS 64054-40-6) References
1 Li, M., Thompson, D.D., Paralkar, V.M. Prostaglandin E2 receptors in bone formation. International Orthopaedics 31 767-772 (2007). 2 Hawcroft, G., Ko, C.W.S., Hull, M.A. Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells. Oncogene 26 3006-3019 (2007). 3 Babaev, V.R., Chew, J.D., Ding, L., et al. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metabolism 8 492-501 (2008). 4 Billot, X., Chateauneuf, A., Chauret, N., et al. Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg Medicinal Chem Letter 13 1129-1132 (2003). 5 Smith, R.L., Lee, T., Gould, N.P., et al. Prostaglandin isosteres. 1. (8-Aza-, 8,10-Diaza-, and 8-Aza-11-thia)-9-oxoprostanoic acids and their derivatives. J Med Chem 20(10) 1292-1299 (1977).Activator of:
EP2, and EP4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid, 500 µg | sc-223250 | 500 µg | $114.00 | |||
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid, 1 mg | sc-223250A | 1 mg | $216.00 |