2,3-dinor Thromboxane B1
Molecular Weight:
344.4
Molecular Formula:
C18H32O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2(1). In rabbits and rats, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2(2,3). However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified(2). In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively)(2). Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats.
2,3-dinor Thromboxane B1 References
1 Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim Biophys Acta 992 66-70 (1989). 2 Chiabrando, C., Corada, M., Bachi, A., et al. Urinary excretion of 2,3-dinor-thromboxane B1, a major metabolite of thromboxane B2 in the rat. Prostaglandins 47 409-422 (1994). 3 Westlund, P., Kumlin, M., Nordenström, A., et al. Circulating and urinary thromboxane B2 metabolites in the rabbit: 11-dehydro-thromboxane B2 as parameter of thromboxane production. Prostaglandins 31(3) 413-443 (1986).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,3-dinor Thromboxane B1, 25 µg | sc-223466 | 25 µg | $143.00 | |||
2,3-dinor Thromboxane B1, 50 µg | sc-223466A | 50 µg | $272.00 |