Date published: 2026-5-19

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2,3-dinor-8-iso Prostaglandin F2α (CAS 221664-05-7)

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Application:
2,3-dinor-8-iso Prostaglandin F2α is an F2 isoprostane metabolite produced via peroxidation of arachidonic acid
CAS Number:
221664-05-7
Molecular Weight:
326.4
Molecular Formula:
C18H30O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,3-dinor-8-iso Prostaglandin F2α (2,3-dinor-8-epi-PGF2α) hinges on its interaction with a specific cell membrane receptor, referred to as the prostaglandin F receptor (FP). Activation of this receptor initiates a cascade of intracellular reactions, culminating in the generation of molecules like cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). These molecules operate as signaling agents, triggering diverse cellular responses, including the relaxation of smooth muscle cells and the release of anti-inflammatory compounds.


2,3-dinor-8-iso Prostaglandin F2α (CAS 221664-05-7) References

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  2. Metabolomics reveals metabolic biomarkers of Crohn's disease.  |  Jansson, J., et al. 2009. PLoS One. 4: e6386. PMID: 19636438
  3. Quantification of the oxidative damage biomarker 2,3-dinor-8-isoprostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry.  |  Zhang, H., et al. 2010. Anal Biochem. 399: 302-4. PMID: 20026293
  4. Effect of exercise on oxidative stress: a 12-month randomized, controlled trial.  |  Campbell, PT., et al. 2010. Med Sci Sports Exerc. 42: 1448-53. PMID: 20139793
  5. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.  |  Morrow, JD., et al. 1990. Proc Natl Acad Sci U S A. 87: 9383-7. PMID: 2123555
  6. Quantification of fatty acid oxidation products using online high-performance liquid chromatography tandem mass spectrometry.  |  Levison, BS., et al. 2013. Free Radic Biol Med. 59: 2-13. PMID: 23499838
  7. Isoprostanes in wastewater as biomarkers of oxidative stress during COVID-19 pandemic.  |  Bowers, I. and Subedi, B. 2021. Chemosphere. 271: 129489. PMID: 33434819
  8. Exometabolomic Analysis of Decidualizing Human Endometrial Stromal and Perivascular Cells.  |  Harden, SL., et al. 2021. Front Cell Dev Biol. 9: 626619. PMID: 33585482
  9. Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies.  |  Mukli, P., et al. 2022. Oxid Med Cell Longev. 2022: 6110226. PMID: 35571254
  10. Multi-Omics Analysis of the Microbiome and Metabolome Reveals the Relationship Between the Gut Microbiota and Wooden Breast Myopathy in Broilers.  |  Kang, K., et al. 2022. Front Vet Sci. 9: 922516. PMID: 35812872
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  13. Isoprostanes. Novel markers of endogenous lipid peroxidation and potential mediators of oxidant injury.  |  Roberts, LJ. and Morrow, JD. 1994. Ann N Y Acad Sci. 744: 237-42. PMID: 7825845
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,3-dinor-8-iso Prostaglandin F2α, 25 µg

sc-205096
25 µg
$163.00

2,3-dinor-8-iso Prostaglandin F2α, 50 µg

sc-205096A
50 µg
$311.00