Molecular structure of 2,3-dinor-11β-Prostaglandin F2α, CAS Number: 240405-20-3
2,3-dinor-11β-Prostaglandin F2α (CAS 240405-20-3)
Alternate Names:
2,3-dinor-11β-PGF2α; 2,3-dinor-11-epi PGF2α
Application:
2,3-dinor-11β-Prostaglandin F2α is a major F2 isoprostane produced non-enzymatically from arachidonic acid
CAS Number:
240405-20-3
Molecular Weight:
326.4
Molecular Formula:
C18H30O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2,3-dinor-11β-Prostaglandin F2α, a major F2 isoprostane metabolite, has been shown to be produced in vivo by free radical-dependent peroxidation of arachidonic acid (sc-200770). This non-enzymatic production of prostaglandins is thought to limit the efficacy of COX-2 inhibitors, and could potentially be used as a measure of oxidative stress. It has been suggested that 2,3-dinor-11β-Prostaglandin F2α may play a role in inflammation, as increased levels have been observed in cases of asthma and mastocytosis.
2,3-dinor-11β-Prostaglandin F2α (CAS 240405-20-3) References
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- Oxylipin Response to Acute and Chronic Exercise: A Systematic Review. | Signini, ÉF., et al. 2020. Metabolites. 10: PMID: 32630487
- Reply to Thomson: Exposure to Active and Passive Tobacco Smoke on Urinary Eicosanoid Metabolites in Type 2 Asthma. | Kolmert, J., et al. 2021. Am J Respir Crit Care Med. 203: 1204-1205. PMID: 33621476
- Differential mast cell mediators in systemic mastocytosis and hereditary α-tryptasemia. | Giannetti, MP., et al. 2022. J Allergy Clin Immunol. 150: 1225-1227. PMID: 35550148
- Increased Excretion of Mast Cell Mediator Metabolites During Mast Cell Activation Syndrome. | Butterfield, JH. 2023. J Allergy Clin Immunol Pract. 11: 2542-2546. PMID: 36863614
- Integrated Analysis of Transcriptome and Metabolome Provides Insight into Camellia oleifera Oil Alleviating Fat Accumulation in High-Fat Caenorhabditis elegans. | Liu, L., et al. 2023. Int J Mol Sci. 24: PMID: 37511379
- Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α. | Moehnke, K., et al. 2024. Clin Biochem. 126: 110745. PMID: 38462204
- Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. | Liston, TE. and Roberts, LJ. 1985. J Biol Chem. 260: 13172-80. PMID: 3863815
- Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. | Roberts, LJ. and Sweetman, BJ. 1985. Prostaglandins. 30: 383-400. PMID: 3864190
- Reduction of urinary 8-epi-prostaglandin F2 alpha during cyclo-oxygenase inhibition in rats but not in man. | Bachi, A., et al. 1997. Br J Pharmacol. 121: 1770-4. PMID: 9283716
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,3-dinor-11β-Prostaglandin F2α, 25 µg | sc-205095 | 25 µg | $112.00 | |||
2,3-dinor-11β-Prostaglandin F2α, 50 µg | sc-205095A | 50 µg | $214.00 |