Date published: 2026-1-13

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2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone (CAS 14918-69-5)

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CAS Number:
14918-69-5
Molecular Weight:
259.04
Molecular Formula:
C10H4Cl2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone is a occurring compound found in certain plants and fungi. It is involved in the biosynthesis of vitamin K, which plays a role in blood clotting and bone metabolism. 2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone is a key intermediate in the pathway that leads to the production of vitamin K, making it an important molecule in the field of biochemistry. Through a series of enzymatic reactions, 2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone is converted into menaquinone. The structure of 2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone allows it to participate in redox reactions, making it a component in the vitamin K cycle.


2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone (CAS 14918-69-5) References

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  2. Induction of p73beta by a naphthoquinone analog is mediated by E2F-1 and triggers apoptosis in HeLa cells.  |  Kang, KH., et al. 2002. FEBS Lett. 522: 161-7. PMID: 12095638
  3. Involvement of Akt in mitochondria-dependent apoptosis induced by a cdc25 phosphatase inhibitor naphthoquinone analog.  |  Kim, HJ., et al. 2003. FEBS Lett. 555: 217-22. PMID: 14644418
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  5. Synthesis of echinamines A and B, the first aminated hydroxynaphthazarins produced by the sea urchin Scaphechinus mirabilis and its analogues.  |  Pokhilo, ND., et al. 2006. J Nat Prod. 69: 1125-9. PMID: 16933861
  6. Valence-state analysis through spectroelectrochemistry in a series of quinonoid-bridged diruthenium complexes [(acac)(2)Ru(mu-L)Ru(acac)(2)](n) (n=+2, +1, 0, -1, -2).  |  Ghumaan, S., et al. 2008. Chemistry. 14: 10816-28. PMID: 18924186
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  8. Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.  |  Shang, XF., et al. 2018. Sci Rep. 8: 1609. PMID: 29371639
  9. The antioxidant 2,3-dichloro,5,8-dihydroxy,1,4-naphthoquinone inhibits acetyl-cholinesterase activity and amyloid β42 aggregation: A dual target therapeutic candidate compound for the treatment of Alzheimer's disease.  |  Khelifi, I., et al. 2020. Biotechnol Appl Biochem. 67: 983-990. PMID: 31820491
  10. Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer's Disease.  |  Campora, M., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 33466332
  11. Identification of Vitamin K3 and its analogues as covalent inhibitors of SARS-CoV-2 3CLpro.  |  Wang, R., et al. 2021. Int J Biol Macromol. 183: 182-192. PMID: 33901557
  12. Synthesis and Antimalarial Activities of New Hybrid Atokel Molecules.  |  Li, Y., et al. 2022. ChemistryOpen. 11: e202200064. PMID: 35543215
  13. Study on the Chemical Composition and the Biological Activities of Vitis vinifera Stem Extracts.  |  Ben Khadher, T., et al. 2022. Molecules. 27: PMID: 35630586

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone, 1 g

sc-486368
1 g
$245.00