Molecular structure of 2,3-Diaminonaphthalene, CAS Number: 771-97-1
2,3-Diaminonaphthalene (CAS 771-97-1)
Alternate Names:
DAN
Application:
2,3-Diaminonaphthalene is an inhibitor of nitric oxide formation
CAS Number:
771-97-1
Purity:
≥95%
Molecular Weight:
158.20
Molecular Formula:
C10H10N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2,3-Diaminonaphthalene is an inhibitor of nitric oxide (NO) formation. The relatively nonfluorescent DAN reacts rapidly with the NO-derived N-nitrosating agent(s) to yield the highly fluorescent product 2,3-naphthotriazole (NAT). Has been used to develop enhanced detection methods for nitric oxide (NO) in living cells and tissue culture systems required in the search for novel NO synthase (NOS) inhibitors.
2,3-Diaminonaphthalene (CAS 771-97-1) References
- The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate. | Jourd'heuil, D., et al. 1999. Arch Biochem Biophys. 365: 92-100. PMID: 10222043
- Sources of interference in the use of 2,3-diaminonaphthalene for the fluorimetric determination of nitric oxide synthase activity in biological samples. | Fernández-Cancio, M., et al. 2001. Clin Chim Acta. 312: 205-12. PMID: 11580928
- Fluorescent derivatization of nitrite ions with 2,3-diaminonaphthalene utilizing a pH gradient in a Y-shaped microchannel. | Odake, T., et al. 2001. Anal Sci. 17: 535-8. PMID: 11990573
- A simple HPLC-fluorescence detection of nitric oxide in cultivated plant cells by in situ derivatization with 2,3-diaminonaphthalene. | Wada, M., et al. 2002. Anal Sci. 18: 631-4. PMID: 12083545
- Immobilization and characterization of 2,3-diaminonaphthalene/cyclodextrin complexes in a sol-gel matrix: a new fluorimetric sensor for nitrite. | Martínez-Tomé, MJ., et al. 2009. J Fluoresc. 19: 119-25. PMID: 18642065
- Fluorometric determination of nitrite with 2,3-diaminonaphthalene by reverse phase HPLC under alkaline conditions. | Fang, YI., et al. 2009. J Pharmacol Toxicol Methods. 59: 153-5. PMID: 19504656
- Solid phase extraction--multisyringe flow injection system for the spectrophotometric determination of selenium with 2,3-diaminonaphthalene. | Serra, AM., et al. 2010. Talanta. 81: 572-7. PMID: 20188964
- Selenium speciation in tea by dispersive liquid-liquid microextraction coupled to high-performance liquid chromatography after derivatization with 2,3-diaminonaphthalene. | Zhou, Q., et al. 2015. J Sep Sci. 38: 1577-83. PMID: 25677605
- Mechanism for nitrosation of 2,3-diaminonaphthalene by Escherichia coli: enzymatic production of NO followed by O2-dependent chemical nitrosation. | Ji, XB. and Hollocher, TC. 1988. Appl Environ Microbiol. 54: 1791-4. PMID: 3046492
- PH Control in the fluorometric assay for selenium with 2,3-diaminonaphthalene. | Bayfield, RF. and Romalis, LF. 1985. Anal Biochem. 144: 569-76. PMID: 3993917
- A fluorometric assay for the measurement of nitrite in biological samples. | Misko, TP., et al. 1993. Anal Biochem. 214: 11-6. PMID: 7504409
- Determination of nitric oxide using fluorescence spectroscopy. | Miles, AM., et al. 1996. Methods Enzymol. 268: 105-20. PMID: 8782577
- Determination of selectivity of reactive nitrogen oxide species for various substrates. | Wink, DA., et al. 1996. Methods Enzymol. 268: 120-30. PMID: 8782578
- Intensity-independent fluorometric detection of cellular nitric oxide release. | Andrew, PJ., et al. 1997. FEBS Lett. 408: 319-23. PMID: 9188785
- Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors. | Nakatsubo, N., et al. 1998. Biol Pharm Bull. 21: 1247-50. PMID: 9881632
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NOS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,3-Diaminonaphthalene, 100 mg | sc-202882 | 100 mg | $60.00 |