Molecular structure of 2,3-DCPE, CAS Number: 1009555-55-8
2,3-DCPE (CAS 1009555-55-8)
See product citations (3)
Alternate Names:
2-[[3-(2,3-dichlorophenoxy)propyl]amino]-ethanol, monohydrochloride
Application:
2,3-DCPE is a compound that induces both upregulation and S-phase arrest in p21
CAS Number:
1009555-55-8
Purity:
≥98%
Molecular Weight:
300.60
Molecular Formula:
C11H15Cl2NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2,3 DCPE displays antitumor agent properties and induces ERK activation in research. Causes apoptosis in many tumor cell lines and is known to specifically cleave caspase-8, caspase-3, caspase-9, and poly(ADP-ribose) polymerase in cancer cells, but not in human fibroblasts. Shown to reduce the protein level of Bcl-XL. Triggered cell death in OAW42-R ovarian carcinoma cells with inhibition of Bcl-2 expression and increased cytotoxic effect of cisplatin in OAW42-R resistant cells. 2,3-DCPE reported to induce S-phase arrest and upregulate p21.
2,3-DCPE (CAS 1009555-55-8) References
- Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol. | Wu, S., et al. 2004. Cancer Res. 64: 1110-3. PMID: 14871845
- Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. | Zhu, H., et al. 2004. Oncogene. 23: 4984-92. PMID: 15122344
- Cell cycle arrest and proapoptotic effects of the anticancer cyclodepsipeptide serratamolide (AT514) are independent of p53 status in breast cancer cells. | Soto-Cerrato, V., et al. 2005. Biochem Pharmacol. 71: 32-41. PMID: 16298346
- Anticancer and chemosensitizing effects of 2,3-DCPE in ovarian carcinoma cell lines: link with ERK activation and modulation of p21WAF1/CIP1, Bcl-2 and Bcl-xL expression. | Villedieu, M., et al. 2007. Gynecol Oncol. 105: 373-84. PMID: 17276501
- Synergistic efficacy of a novel combination therapy controls growth of Bcl-x(L) bountiful neuroblastoma cells by increasing differentiation and apoptosis. | Mohan, N., et al. 2011. Cancer Biol Ther. 12: 846-54. PMID: 21878749
- Optimized anti-tumor effects of anthracyclines plus Vinca alkaloids using a novel, mechanism-based application schedule. | Ehrhardt, H., et al. 2011. Blood. 118: 6123-31. PMID: 21926351
- Activation of human herpesvirus replication by apoptosis. | Prasad, A., et al. 2013. J Virol. 87: 10641-50. PMID: 23885073
- Hedyotis diffusa Willd extract inhibits the growth of human glioblastoma cells by inducing mitochondrial apoptosis via AKT/ERK pathways. | Zhang, Y., et al. 2014. J Ethnopharmacol. 158 Pt A: 404-11. PMID: 25456437
- 3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells. | Wang, Y., et al. 2017. Int J Oncol. 50: 1392-1402. PMID: 28259974
- Small molecule 2,3-DCPE induces S phase arrest by activating the ATM/ATR-Chk1-Cdc25A signaling pathway in DLD-1 colon cancer cells. | Bai, B., et al. 2020. Oncol Lett. 20: 294. PMID: 33101488
- CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle-Dependent Degradation of CDK2. | Riching, KM., et al. 2021. SLAS Discov. 26: 560-569. PMID: 33190579
- Non-ubiquitous expression of core spliceosomal protein SmB/B' in chick and mouse embryos. | Turner, BRH., et al. 2023. Dev Dyn. 252: 276-293. PMID: 36058892
- Abstract C022: Large scale phenotypic screening using PRISM, integrated with functional genomic screening and transcriptional profiling accelerates target identification of cytotoxic small molecules | Larpenteur, K., Waal, L. D., Wang, L., Kocak, M., Bryan, J., Bender, S.,.. & Roth, J. 2019. Molecular Cancer Therapeutics. 18(12_Supplement): C022-C022.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,3-DCPE, 10 mg | sc-200139 | 10 mg | $119.00 | |||
2,3-DCPE, 50 mg | sc-200139A | 50 mg | $288.00 |