Date published: 2026-3-6

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2-(3-Chloropropyl)-2-methyl-1,3-dioxolane (CAS 5978-08-5)

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Alternate Names:
5-Chloro-2-pentanone ethylene ketal
Application:
2-(3-Chloropropyl)-2-methyl-1,3-dioxolane is used in the preparation of 7-[(4,4-Ethylenedioxy)pentoxy]-2H-1-benzopyran-2-one
CAS Number:
5978-08-5
Molecular Weight:
164.63
Molecular Formula:
C7H13ClO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-(3-Chloropropyl)-2-methyl-1,3-dioxolane, known as CPMD, is a synthetic organic compound that has garnered significant attention in scientific research due to its distinct characteristics. 2-(3-Chloropropyl)-2-methyl-1,3-dioxolane is a cyclic ether featuring a chloropropyl group and a methyl group. It presents as a colorless liquid that exhibits high solubility in both water and organic solvents. The unique properties of 2-(3-Chloropropyl)-2-methyl-1,3-dioxolane have made it widely employed in scientific research. It serves as a solvent, reagent, and intermediate in the synthesis of diverse organic compounds. Furthermore, 2-(3-Chloropropyl)-2-methyl-1,3-dioxolane finds utility as a chiral auxiliary in asymmetric synthesis. Notably, it has been utilized as a probe in NMR spectroscopy to explore the structure and dynamics of proteins and nucleic acids. While the precise mechanism of action of 2-(3-Chloropropyl)-2-methyl-1,3-dioxolane remains elusive, it is believed that the compound can establish covalent bonds with amino acid residues in proteins, thereby inducing alterations in their conformation and activity. Additionally, 2-(3-Chloropropyl)-2-methyl-1,3-dioxolane has demonstrated an ability to influence the stability and functionality of nucleic acids.


2-(3-Chloropropyl)-2-methyl-1,3-dioxolane (CAS 5978-08-5) References

  1. C-alkylation of chiral tropane- and homotropane-derived enamines.  |  Hodgson, DM., et al. 2013. J Org Chem. 78: 1508-18. PMID: 23356473
  2. High yield conversion of doxorubicin to 2-pyrrolinodoxorubicin, an analog 500-1000 times more potent: structure-activity relationship of daunosamine-modified derivatives of doxorubicin.  |  Nagy, A., et al. 1996. Proc Natl Acad Sci U S A. 93: 2464-9. PMID: 8637897

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-(3-Chloropropyl)-2-methyl-1,3-dioxolane, 5 g

sc-223249
5 g
$50.00