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2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone (CAS 55094-52-5)

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Alternate Names:
2,3,5-Tri-O-benzyl-D-ribonic acid-1,4-lactone
CAS Number:
55094-52-5
Molecular Weight:
418.48
Molecular Formula:
C26H26O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is an organic compound extensively used as a synthetic intermediate in the field of carbohydrate chemistry. Its protected form, with the benzyl groups guarding the hydroxyl functionalities, allows for selective reactions to occur at the remaining reactive sites of the sugar molecule. This specificity is in the stepwise synthesis of complex oligosaccharides, where precise control over the formation of glycosidic linkages is necessary. In addition, this lactone serves as a starting material for the synthesis of nucleoside analogs, which are compounds of interest due to their role as building blocks in the study of RNA and DNA analogs. Furthermore, the benzyl groups can be removed under certain conditions, revealing the free sugar molecule, which can then be employed in various enzymatic reactions to investigate biological pathways or to produce naturally occurring sugar derivatives for research.


2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone (CAS 55094-52-5) References

  1. Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines.  |  Minasov, G., et al. 2000. RNA. 6: 1516-28. PMID: 11105752
  2. A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir.  |  Liang, C., et al. 2020. Eur J Med Chem. 201: 112527. PMID: 32563812
  3. Discovery of fungal surface NADases predominantly present in pathogenic species.  |  Strømland, Ø., et al. 2021. Nat Commun. 12: 1631. PMID: 33712585
  4. A One-Pot Approach to Novel Pyridazine C-Nucleosides.  |  Cermola, F., et al. 2021. Molecules. 26: PMID: 33920588

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone, 1 g

sc-283373
1 g
$61.00

2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone, 5 g

sc-283373A
5 g
$184.00