2,3,5-Tri-O-benzyl-D-ribofuranose (CAS 89615-45-2)

2,3,5-Tri-O-benzyl-D-ribofuranose is a chemical compound extensively utilized in carbohydrate chemistry research, particularly in the synthesis of modified nucleosides and nucleotides. Its primary mechanism of action lies in its ability to serve as a key building block for the construction of nucleoside analogs, where the ribose moiety plays a crucial role in maintaining structural similarity to natural nucleosides while imparting altered properties. This compound has been employed in the development of nucleoside-based targets, including antiviral and anticancer agents, by introducing modifications to the sugar backbone to enhance bioavailability, pharmacokinetics, and target specificity. Furthermore, 2,3,5-Tri-O-benzyl-D-ribofuranose has been instrumental in the synthesis of modified nucleic acid probes for various research applications, such as gene expression analysis, RNA interference studies, and nucleic acid-based biosensors. Its versatility in nucleoside chemistry has also facilitated the exploration of structure-activity relationships and the design of novel nucleoside analogs with improved biological activity and selectivity. Overall, this compound serves as a valuable tool for advancing our understanding of nucleic acid biochemistry and for the development of nucleoside-based research tools.