Date published: 2026-4-25
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2,3,4,7,8-Pentachlorodibenzofuran (CAS 57117-31-4)

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CAS Number:
57117-31-4
Purity:
≥90%
Molecular Weight:
340.42
Molecular Formula:
C12H3Cl5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

2,3,4,7,8-Pentachlorodibenzofuran is a chlorinated organic compound that is primarily used in environmental chemistry research as a model pollutant. Given its structural similarity to dioxins, it is often studied to understand the environmental persistence, toxicological profile, and bioaccumulation tendencies of this class of compounds. Research involving 2,3,4,7,8-Pentachlorodibenzofuran includes investigations into its formation and degradation pathways, particularly in the context of combustion processes and chemical manufacturing. Additionally, this compound is used as a reference standard in the analysis of complex environmental samples to quantify and assess the presence of related toxic contaminants. The study of 2,3,4,7,8-Pentachlorodibenzofuran also aids in the development of remediation strategies aimed at reducing the impact of such persistent organic pollutants on ecosystems and human health.


2,3,4,7,8-Pentachlorodibenzofuran (CAS 57117-31-4) References

  1. Effects of CYP1A2 on disposition of 2,3,7, 8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,2',4,4',5,5'-hexachlorobiphenyl in CYP1A2 knockout and parental (C57BL/6N and 129/Sv) strains of mice.  |  Diliberto, JJ., et al. 1999. Toxicol Appl Pharmacol. 159: 52-64. PMID: 10448125
  2. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran reduces growth and disrupts reproductive parameters in female rats.  |  Salisbury, TB. and Marcinkiewicz, JL. 2002. Biol Reprod. 66: 1621-6. PMID: 12021039
  3. Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.  |  Budinsky, RA., et al. 2010. Toxicol Sci. 118: 224-35. PMID: 20705892
  4. 2,3,4,7,8-pentachlorodibenzofuran is a more potent cytochrome P4501A inducer than 2,3,7,8-tetrachlorodibenzo-p-dioxin in herring gull hepatocyte cultures.  |  Hervé, JC., et al. 2010. Environ Toxicol Chem. 29: 2088-95. PMID: 20821667
  5. Transcriptional profiles induced by the Aryl Hydrocarbon Receptor agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran in primary rat hepatocytes.  |  Rowlands, JC., et al. 2011. Chemosphere. 85: 232-8. PMID: 21724226
  6. Relative toxicity and tumor-promoting ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PCDF), and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF) in hairless mice.  |  Hébert, CD., et al. 1990. Toxicol Appl Pharmacol. 102: 362-77. PMID: 2300974
  7. Age-related changes in dermal absorption of 2,3,7, 8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran.  |  Banks, YB., et al. 1990. Fundam Appl Toxicol. 15: 163-73. PMID: 2373296
  8. Purification and characterization of two forms of 2,3,4,7,8-pentachlorodibenzofuran-inducible cytochrome P-450 in hamster liver.  |  Koga, N., et al. 1990. J Biochem. 107: 826-33. PMID: 2391346
  9. 2,3,4,7,8-Pentachlorodibenzofuran is far less potent than 2,3,7,8-tetrachlorodibenzo-p-dioxin in disrupting the pituitary-gonad axis of the rat fetus.  |  Taura, J., et al. 2014. Toxicol Appl Pharmacol. 281: 48-57. PMID: 25220434
  10. [Effect of Cynaropicrin on 2,3,4,7,8-Pentachlorodibenzofuran-induced Wasting Syndrome and Oxidative Stress].  |  Yamada, K., et al. 2015. Fukuoka Igaku Zasshi. 106: 169-75. PMID: 26226680
  11. Developmental toxicity of 2,3,4,7,8-pentachlorodibenzofuran in the Fischer 344 rat.  |  Couture, LA., et al. 1989. Fundam Appl Toxicol. 12: 358-66. PMID: 2714534
  12. The acute toxicity of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the male Fischer rat.  |  Brewster, DW., et al. 1988. Fundam Appl Toxicol. 11: 236-49. PMID: 3220203
  13. Toxicity and disposition of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the rhesus monkey (Macaca mulatta).  |  Brewster, DW., et al. 1988. Toxicol Appl Pharmacol. 93: 231-46. PMID: 3358261
  14. Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat.  |  Brewster, DW. and Birnbaum, LS. 1987. Toxicol Appl Pharmacol. 90: 243-52. PMID: 3629600
  15. High accumulation of 2,3,4,7,8-pentachlorodibenzofuran to hepatic microsomes of rats.  |  Yoshimura, H., et al. 1984. J Pharmacobiodyn. 7: 414-9. PMID: 6090636

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Product NameCatalog #UNITPriceQtyFAVORITES

2,3,4,7,8-Pentachlorodibenzofuran, 5 mg

sc-477344
5 mg
$320.00
1-800-457-3801
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