Date published: 2025-10-18

1-800-457-3801

SCBT Portrait Logo
Seach Input

2,3,4,5,6-Pentafluorobenzyl bromide (CAS 1765-40-8)

5.0(1)
Write a reviewAsk a question

Alternate Names:
α-Bromo-2,3,4,5,6-pentafluorotoluene; (Bromomethyl)pentafluorobenzene; Pentafluorobenzyl bromide
CAS Number:
1765-40-8
Molecular Weight:
260.99
Molecular Formula:
C6F5CH2Br
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

2,3,4,5,6-Pentafluorobenzyl bromide functions as a versatile building block in organic synthesis. It acts as an effective brominating agent, facilitating the introduction of the pentafluorobenzyl group into various organic molecules. 2,3,4,5,6-Pentafluorobenzyl Bromide′s mechanism of action involves the substitution of hydrogen atoms with bromine atoms, leading to the formation of new carbon-bromine bonds. This process is particularly useful in the modification of aromatic compounds, enabling the synthesis of diverse chemical intermediates and functionalized molecules. Through its reactivity, 2,3,4,5,6-Pentafluorobenzyl bromide plays a key role in the development of novel materials and agrochemicals by enabling the creation of complex molecular structures with specific properties and functionalities. Its ability to undergo selective bromination reactions may be useful in the exploration of new chemical entities and the optimization of molecular properties for various applications in research and development.


2,3,4,5,6-Pentafluorobenzyl bromide (CAS 1765-40-8) References

  1. Determination of misoprostol free acid in human breast milk and serum by gas chromatography/negative ion chemical ionization tandem mass spectrometry.  |  Watzer, B., et al. 2002. J Mass Spectrom. 37: 927-33. PMID: 12271435
  2. Determination of pentachlorophenol in wastewater irrigated soils and incubated earthworms.  |  Liu, Y., et al. 2006. Talanta. 69: 1254-9. PMID: 18970711
  3. Quantification of two urinary metabolites of organophosphorus flame retardants by solid-phase extraction and gas chromatography-tandem mass spectrometry.  |  Schindler, BK., et al. 2009. Anal Bioanal Chem. 395: 1167-71. PMID: 19763550
  4. An isotope-dilution, GC-MS assay for formate and its application to human and animal metabolism.  |  Lamarre, SG., et al. 2014. Amino Acids. 46: 1885-91. PMID: 24748098
  5. Determination of 2-, 3-, 4-methylpentanoic and cyclohexanecarboxylic acids in wine: development of a selective method based on solid phase extraction and gas chromatography-negative chemical ionization mass spectrometry and its application to different wines and alcoholic beverages.  |  Gracia-Moreno, E., et al. 2015. J Chromatogr A. 1381: 210-8. PMID: 25601317
  6. Dialkyl phosphates determination by gas chromatography: Evaluation of a microwave-assisted derivatization†.  |  Silvério, AC., et al. 2015. J Sep Sci. 38: 2664-9. PMID: 25989312
  7. Determination of Nerve Agent Metabolites by Ultraviolet Femtosecond Laser Ionization Mass Spectrometry.  |  Hamachi, A., et al. 2017. Anal Chem. 89: 5030-5035. PMID: 28372358
  8. Simultaneous determination of seven perfluoroalkyl carboxylic acids in water samples by 2,3,4,5,6-pentafluorobenzyl bromide derivatization and gas chromatography-mass spectrometry.  |  Ji, Y., et al. 2020. Environ Pollut. 266: 115043. PMID: 32623247
  9. Analysis of Hop-Derived Thiols in Beer Using On-Fiber Derivatization in Combination with HS-SPME and GC-MS/MS.  |  Dennenlöhr, J., et al. 2020. J Agric Food Chem. 68: 15036-15047. PMID: 33274918
  10. GC-MS Analysis of Biological Nitrate and Nitrite Using Pentafluorobenzyl Bromide in Aqueous Acetone: A Dual Role of Carbonate/Bicarbonate as an Enhancer and Inhibitor of Derivatization.  |  Tsikas, D. 2021. Molecules. 26: PMID: 34834091
  11. Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine.  |  Bollenbach, A., et al. 2022. Molecules. 27: PMID: 36014446
  12. Determination of N-7-[2H3]methyl guanine in rat urine by gas chromatography-mass spectrometry following administration of trideuteromethylating agents or precursors.  |  Shuker, DE., et al. 1984. Anal Biochem. 140: 270-5. PMID: 6486413
  13. Design, synthesis, and characterization of linear fluorinated poly(benzyl ether)s: A comparison study with isomeric hyperbranched fluoropolymers  |  Kenya T. Powell,a Chong Cheng,a Chakravarthy S. Gudipatia and Karen L. Wooley*a. 2005. J. Mater. Chem. 15: 5128-5135.
  14. An isotope-dilution, GC–MS assay for formate and its application to human and animal metabolism  |  Simon G. Lamarre, Luke MacMillan, Gregory P. Morrow, Edward Randell, Theerawat Pongnopparat, Margaret E. Brosnan & John T. Brosnan. 2014. Amino Acids. 46: 1885–1891.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,3,4,5,6-Pentafluorobenzyl bromide, 1 g

sc-471935
1 g
$22.00