Date published: 2025-10-20

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2,2′,4,4′-Tetrahydroxybenzophenone (CAS 131-55-5)

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CAS Number:
131-55-5
Molecular Weight:
246.22
Molecular Formula:
C13H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,2′,4,4′-Tetrahydroxybenzophenone (THBP) is a versatile phenolic compound widely utilized in the chemical and cosmetic industries. Its colorless, crystalline form makes it easily soluble in water, ethanol, and other organic solvents. Additionally, it has proven beneficial as a UV absorber and antioxidant in the cosmetics sector. Despite these promising applications, the exact mechanism of action for 2,2′,4,4′-Tetrahydroxybenzophenone remains not fully comprehended. Current theories suggest that it functions by inhibiting several enzymes, including cyclooxygenase and lipoxygenase. Furthermore, 2,2′,4,4′-Tetrahydroxybenzophenone may contribute as an antioxidant, effectively neutralizing free radicals and countering oxidative damage. 2,2′,4,4′-Tetrahydroxybenzophenone exhibits a wide range of uses in diverse industries and has garnered significant scientific interest due to its potential. However, further research is required to fully elucidate its mechanism of action and unlock its complete potential for various applications.


2,2′,4,4′-Tetrahydroxybenzophenone (CAS 131-55-5) References

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  2. [Estrogenic activity of ultraviolet absorbers and the related compounds].  |  Matsumoto, H., et al. 2005. Yakugaku Zasshi. 125: 643-52. PMID: 16079615
  3. Effect of 2,2',4,4'-tetrahydroxybenzophenone (BP2) on steroidogenesis in testicular Leydig cells.  |  Kim, Y., et al. 2011. Toxicology. 288: 18-26. PMID: 21726595
  4. Pseudopolymorphism in hydroxybenzophenones: the dihydrate of 2,2',4,4'-tetrahydroxybenzophenone.  |  Landre, IM., et al. 2012. Acta Crystallogr C. 68: o156-9. PMID: 22476147
  5. Ovariectomized mouse uterotrophic assay of 36 chemicals.  |  Ohta, R., et al. 2012. J Toxicol Sci. 37: 879-89. PMID: 23037998
  6. Photoexcited states of UV absorbers, benzophenone derivatives.  |  Kumasaka, R., et al. 2014. Photochem Photobiol. 90: 727-33. PMID: 24571426
  7. Urinary concentrations of benzophenone-type ultraviolet radiation filters and couples' fecundity.  |  Buck Louis, GM., et al. 2014. Am J Epidemiol. 180: 1168-75. PMID: 25395025
  8. Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality.  |  Buck Louis, GM., et al. 2015. Fertil Steril. 104: 989-996. PMID: 26253817
  9. Couples' urinary concentrations of benzophenone-type ultraviolet filters and the secondary sex ratio.  |  Bae, J., et al. 2016. Sci Total Environ. 543: 28-36. PMID: 26575635
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  14. [2,2',4,4'-tetrahydroxybenzophenone as a new aldose reductase inhibitor (author's transl)].  |  Ono, H. and Hayano, S. 1982. Nippon Ganka Gakkai Zasshi. 86: 353-7. PMID: 6810663

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,2′,4,4′-Tetrahydroxybenzophenone, 25 g

sc-225586
25 g
$61.00