Date published: 2025-10-14

1-800-457-3801

SCBT Portrait Logo
Seach Input

{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid (CAS 166108-71-0)

0.0(0)
Write a reviewAsk a question

Alternate Names:
8-(Fmoc-amino)-3,6-dioxaoctanoic acid
Application:
{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid is a heterobifunctional, hydrophilic spacer
CAS Number:
166108-71-0
Molecular Weight:
385.41
Molecular Formula:
C21H23NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

[2-(2-(Fmoc-amino)ethoxy)ethoxy]acetic acid, used as a spacer in PNA synthesis, is an important compound in peptide chemistry. [2-(2-(Fmoc-amino)ethoxy)ethoxy]acetic acid is a PEG derivative with an Fmoc-protected amine and a carboxylic acid at the terminal position. The hydrophilic nature of the PEG spacer enhances solubility in aqueous environments. The Fmoc group can be deprotected under basic conditions to reveal the free amine, which can then be utilized for subsequent conjugations. Additionally, the terminal carboxylic acid can form a stable amide bond when reacted with primary amine groups in the presence of activators like EDC or DCC.


{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid (CAS 166108-71-0) References

  1. A fluorescence polarization assay for identifying ligands that bind to vascular endothelial growth factor.  |  Peterson, KJ., et al. 2008. Anal Biochem. 378: 8-14. PMID: 18413228
  2. Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain.  |  Boersma, MD., et al. 2008. Protein Sci. 17: 1232-40. PMID: 18467496
  3. 'Clickable' polymer-caged nanobins as a modular drug delivery platform.  |  Lee, SM., et al. 2009. J Am Chem Soc. 131: 9311-20. PMID: 19527027
  4. Random glycopeptide bead libraries for seromic biomarker discovery.  |  Kracun, SK., et al. 2010. J Proteome Res. 9: 6705-14. PMID: 20886906
  5. Development of homomultimers and heteromultimers of lung cancer-specific peptoids.  |  Hooks, JC., et al. 2011. Biopolymers. 96: 567-77. PMID: 22180904
  6. Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles.  |  Rangger, C., et al. 2013. Int J Nanomedicine. 8: 4659-71. PMID: 24353415
  7. Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding.  |  Bonache, MA., et al. 2014. Org Biomol Chem. 12: 8877-87. PMID: 25264745
  8. Reliable diagnosis of murine type 1 diabetes using a panel of autoantigens and 'antigen surrogates' mounted onto a liquid array.  |  Doran, TM., et al. 2015. Mol Biosyst. 11: 3156-63. PMID: 26390856
  9. Hydrophobicity of Antifungal β-Peptides Is Associated with Their Cytotoxic Effect on In Vitro Human Colon Caco-2 and Liver HepG2 Cells.  |  Mora-Navarro, C., et al. 2016. PLoS One. 11: e0149271. PMID: 26992117
  10. Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.  |  Lu, X., et al. 2017. Nat Commun. 8: 15540. PMID: 28598414
  11. 14-Helical β-Peptides Elicit Toxicity against C. albicans by Forming Pores in the Cell Membrane and Subsequently Disrupting Intracellular Organelles.  |  Lee, MR., et al. 2019. Cell Chem Biol. 26: 289-299.e4. PMID: 30581136
  12. Titanium coating with mussel inspired polymer and bio-orthogonal chemistry enhances antimicrobial activity against Staphylococcus aureus.  |  Czuban, M., et al. 2020. Mater Sci Eng C Mater Biol Appl. 116: 111109. PMID: 32806230
  13. Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy.  |  Mann, G., et al. 2021. Chem Commun (Camb). 57: 9438-9441. PMID: 34528945
  14. Probing the cell delivery of synthetic diubiquitin chains.  |  Mandal, S. and Brik, A. 2022. Chem Commun (Camb). 58: 8782-8785. PMID: 35837864

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 500 mg

sc-251686
500 mg
$175.00