Molecular structure of 2,2,5,7,8-Pentamethyl-6-chromanol, CAS Number: 950-99-2
2,2,5,7,8-Pentamethyl-6-chromanol (CAS 950-99-2)
CAS Number:
950-99-2
Molecular Weight:
220.31
Molecular Formula:
C14H20O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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2,2,5,7,8-Pentamethyl-6-chromanol, a derivative of caffeic acid, has demonstrated the ability to inhibit the growth of HL-60 cells. It can also inhibit certain enzymes, including p-hydroxybenzoic acid related to cholesterol creation, and ester hydrochloride essential for bile acid production. Additionally, it exhibits antioxidant and fluorescence properties, making it useful for DNA structure research. In chemiluminescence tests, 2,2,5,7,8-Pentamethyl-6-chromanol can serve as a substitute for pyridine hydrochloride or 4-(dimethylamino)pyridine hydrochloride, as it doesn′t disrupt the reaction.
2,2,5,7,8-Pentamethyl-6-chromanol (CAS 950-99-2) References
- Reaction of 2,2,5,7,8-pentamethyl-6-chromanol, an alpha-tocopherol analogue, with NO in the presence of oxygen. | Nagata, Y., et al. 2000. Bioorg Med Chem Lett. 10: 2709-12. PMID: 11133074
- Co-oxidation of 2,2,5,7,8-pentamethyl-6-chromanol and diphenyl disulfide with 3-chloroperoxybenzoic acid. | Srikendari, EW., et al. 2001. Redox Rep. 6: 191-3. PMID: 11523597
- Androgen antagonist activity by the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol in human prostate carcinoma cells. | Thompson, TA. and Wilding, G. 2003. Mol Cancer Ther. 2: 797-803. PMID: 12939470
- A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. | Kyriakopoulos, CE., et al. 2016. Invest New Drugs. 34: 225-30. PMID: 26924129
- Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum. | Neuwirth, T., et al. 2020. Chemistry. 26: 15855-15858. PMID: 32996646
- Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin-Vitamin E Complex. | Ogawa, S., et al. 2021. Antioxidants (Basel). 10: PMID: 33804761
- Discovery of sterically-hindered phenol compounds with potent cytoprotective activities against ox-LDL-induced retinal pigment epithelial cell death as a potential pharmacotherapy. | Gnanaguru, G., et al. 2022. Free Radic Biol Med. 178: 360-368. PMID: 34843917
- Electrochemical and Mechanistic Study of Reactivities of α-, β-, γ-, and δ-Tocopherol toward Electrogenerated Superoxide in N,N-Dimethylformamide through Proton-Coupled Electron Transfer. | Nakayama, T., et al. 2021. Antioxidants (Basel). 11: PMID: 35052513
- Afamin Levels and Their Correlation with Oxidative and Lipid Parameters in Non-diabetic, Obese Patients. | Juhász, I., et al. 2022. Biomolecules. 12: PMID: 35053264
- Chain-Breaking Antioxidant and Peroxyl Radical Trapping Activity of Phenol-Coated Magnetic Iron Oxide Nanoparticles. | Scurti, S., et al. 2022. Antioxidants (Basel). 11: PMID: 35740061
- Kinetic Analysis of High-Temperature Sunflower Oil Peroxidation Inhibited by the Major Families of Phenolic Antioxidants Unveils the Extraordinary Activity of 1,4-Hydroquinones. | Mollica, F., et al. 2022. Antioxidants (Basel). 11: PMID: 36358514
- Dynamics of microbial populations and metabolites of fermenting saps throughout tapping process of ron and oil palm trees in Côte d'Ivoire. | Djeni, TN., et al. 2022. Front Microbiol. 13: 954917. PMID: 36386638
- Expanding the Use of Peroxygenase from Oat Flour in Organic Synthesis: Enantioselective Oxidation of Sulfides. | Sanfilippo, C., et al. 2023. Int J Mol Sci. 24: PMID: 37108626
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,2,5,7,8-Pentamethyl-6-chromanol, 5 g | sc-225569 | 5 g | $56.00 |