Molecular structure of 2,2,2-Trifluoroethylamine, CAS Number: 753-90-2
2,2,2-Trifluoroethylamine (CAS 753-90-2)
Alternate Names:
2-Amino-1,1,1-trifluoroethane
Application:
2,2,2-Trifluoroethylamine is a catalyst for the isomerisation of unsaturated ketones
CAS Number:
753-90-2
Purity:
≥95%
Molecular Weight:
99.06
Molecular Formula:
C2H4F3N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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2,2,2-Trifluoroethylamine is characterized by the presence of a trifluoroethyl group attached to an amine functional group. This structure imparts unique properties, such as increased lipophilicity and chemical stability, making it a versatile intermediate in chemical synthesis. It participates in the formation of various organic compounds, where the introduction of fluorine atoms is desirable for enhancing the activity and stability of the final products. The amine group in 2,2,2-Trifluoroethylamine facilitates its involvement in nucleophilic substitution reactions, which are fundamental for constructing nitrogen-containing compounds. 2,2,2-Trifluoroethylamine is also used in the synthesis of more complex amines and as a building block in the creation of polymers and surfactants
2,2,2-Trifluoroethylamine (CAS 753-90-2) References
- Synthesis of Chiral α-Trifluoromethylamines with 2,2,2-Trifluoroethylamine as a 'Building Block'. | Li, X., et al. 2016. Org Lett. 18: 956-9. PMID: 26881828
- Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group. | Bungard, CJ., et al. 2016. ACS Med Chem Lett. 7: 702-7. PMID: 27437081
- Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene. | Tinoco, A., et al. 2017. J Am Chem Soc. 139: 5293-5296. PMID: 28366001
- Synthesis of N-Substituted Sulfamate Esters from Sulfamic Acid Salts by Activation with Triphenylphosphine Ditriflate. | Blackburn, JM., et al. 2017. Org Lett. 19: 6012-6015. PMID: 29048913
- Synthesis of 1-Tetrasubstituted 2,2,2-Trifluoroethylamine Derivatives via Palladium-Catalyzed Allylation of sp3 C-H Bonds. | Morisaki, K., et al. 2017. Chem Pharm Bull (Tokyo). 65: 1089-1092. PMID: 29093297
- Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Trypanosoma brucei Inhibitors. | Singh, B., et al. 2020. J Med Chem. 63: 9912-9927. PMID: 32786222
- Detection of an enzyme isomechanism by means of the kinetics of covalent inhibition. | Adediran, SA., et al. 2021. Biochim Biophys Acta Proteins Proteom. 1869: 140681. PMID: 34087495
- A comparison of metabolic labeling and statistical methods to infer genome-wide dynamics of RNA turnover. | Boileau, E., et al. 2021. Brief Bioinform. 22: PMID: 34228787
- Internally controlled RNA sequencing comparisons using nucleoside recoding chemistry. | Courvan, MCS., et al. 2022. Nucleic Acids Res. 50: e110. PMID: 36018791
- Stepwise-Enhanced Tumor Targeting of Near-Infrared Emissive Au Nanoclusters with High Quantum Yields and Long-Term Stability. | Zhu, H., et al. 2022. Anal Chem. 94: 13189-13196. PMID: 36106565
- Determining RNA Natural Modifications and Nucleoside Analog-Labeled Sites by a Chemical/Enzyme-Induced Base Mutation Principle. | Bao, Z., et al. 2023. Molecules. 28: PMID: 36838506
- Luminescent Gold Nanoclusters for Bioimaging: Increasing the Ligand Complexity. | Mordini, D., et al. 2023. Nanomaterials (Basel). 13: PMID: 36839016
- Ligand vacancy channels in pillared inorganic-organic hybrids for electrocatalytic organic oxidation with enzyme-like activities. | Chen, Z., et al. 2023. Nat Commun. 14: 1184. PMID: 36864050
- Hydrophilic Aldehyde-Functional Polymer Brushes: Synthesis, Characterization, and Potential Bioapplications. | Brotherton, EE., et al. 2023. Macromolecules. 56: 2070-2080. PMID: 36938510
- Eco-Friendly Fluorine Functionalized Superhydrophobic/Superoleophilic Zeolitic Imidazolate Frameworks-Based Composite for Continuous Oil-Water Separation. | Xiang, W., et al. 2023. Molecules. 28: PMID: 36985815
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,2,2-Trifluoroethylamine, 1 g | sc-256261 | 1 g | $47.00 |