2,2,2-Trichloroethanol (CAS 115-20-8)
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2,2,2-Trichloroethanol (TCE) is an organic compound extensively utilized as a reagent in laboratory applications and various industrial processes. It plays a significant role in organic synthesis. 2,2,2-Trichloroethanol is a colorless liquid with a pungent odor, known as trichloroethyl alcohol or trichloroethanol, derived from ethanol. Within scientific research, 2,2,2-Trichloroethanol serves various purposes. It is employed as a solvent in organic synthesis. Additionally, 2,2,2-Trichloroethanol contributes to the creation of catalysts like palladium, platinum, and ruthenium. Furthermore, 2,2,2-Trichloroethanol has been employed in synthesizing polymers such as polystyrene and polypropylene. Notably, 2,2,2-Trichloroethanol acts as an alkylating agent, forming covalent bonds through reactions with other molecules. It also possesses strong oxidizing properties, capable of oxidizing other molecules and generating free radicals. These free radicals can subsequently engage in reactions with other molecules, leading to the formation of new compounds.
2,2,2-Trichloroethanol (CAS 115-20-8) References
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- Binding of the general anesthetics chloroform and 2,2,2-trichloroethanol to the hydrophobic core of a four-alpha-helix bundle proteins. | Johansson, JS., et al. 2003. Photochem Photobiol. 77: 89-95. PMID: 12856888
- Arginine 246 of the pretransmembrane domain 1 region alters 2,2,2-trichloroethanol action in the 5-hydroxytryptamine3A receptor. | Hu, XQ. and Peoples, RW. 2008. J Pharmacol Exp Ther. 324: 1011-8. PMID: 18094321
- 2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery. | Parelkar, NK., et al. 2010. J Pharmacol Exp Ther. 332: 803-10. PMID: 19955488
- 2,2,2-Trichloroethanol lengthens the circadian period of Bmal1-driven circadian bioluminescence rhythms in U2OS cells. | Gao, J., et al. 2015. Biochem Biophys Res Commun. 462: 239-44. PMID: 25956065
- Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer. | Pichlo, C., et al. 2018. Acta Crystallogr F Struct Biol Commun. 74: 307-314. PMID: 29717999
- Atomistic Model for Simulations of the Sedative Hypnotic Drug 2,2,2-Trichloroethanol. | Kiametis, AS., et al. 2018. ACS Omega. 3: 15916-15923. PMID: 30556017
- Protein quantification and visualization via ultraviolet-dependent labeling with 2,2,2-trichloroethanol. | Chopra, A., et al. 2019. Sci Rep. 9: 13923. PMID: 31558752
- Trichloroethanol, an active metabolite of chloral hydrate, modulates tetrodotoxin-resistant Na+ channels in rat nociceptive neurons. | Kim, G., et al. 2023. BMC Anesthesiol. 23: 145. PMID: 37120567
- Trichloroethanol potentiation of gamma-aminobutyric acid-activated chloride current in mouse hippocampal neurones. | Peoples, RW. and Weight, FF. 1994. Br J Pharmacol. 113: 555-63. PMID: 7834208
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- A hydrophobic quencher of protein fluorescence: 2,2,2-trichloroethanol. | Eftink, MR., et al. 1977. Biochim Biophys Acta. 491: 473-81. PMID: 857905
- N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine and 2,2,2-trichloroethanol: two novel metabolites of tetrachloroethene in humans after occupational exposure. | Birner, G., et al. 1996. Drug Metab Dispos. 24: 41-8. PMID: 8825189
- Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors. | Krasowski, MD., et al. 1998. J Pharmacol Exp Ther. 284: 934-42. PMID: 9495852
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,2,2-Trichloroethanol, 100 g | sc-256252 | 100 g | $39.00 |