2-(14,15-Epoxyeicosatrienoyl) Glycerol CAS: 848667-56-1
MF: C23H38O5
MW: 394.5
A TACE activator which increases DNA synthesis.

2-(14,15-Epoxyeicosatrienoyl) Glycerol (CAS 848667-56-1)

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Alternate Names: 2-14,15-EG
Application: 2-(14,15-Epoxyeicosatrienoyl) Glycerol is a TACE activator which increases DNA synthesis
CAS Number: 848667-56-1
Purity: ≥95%
Molecular Weight: 394.5
Molecular Formula: C23H38O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

2-(14,15-Epoxyeicosatrienoyl) Glycerol (2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. 2-14,15-EG is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 μM. In these cells, 2-14,15-EG activates the metalloprotease ADAM17 (TACE), which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway.


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Formulation :
A solution in acetonitrile
Physical State :
Solubility :
Soluble in DMSO (~10 mg/ml), DMF (~10 mg/ml), aqueous solutions, and ethanol (~50 mg/ml).
Storage :
Store at -80° C
Boiling Point :
84° C
Refractive Index :
n20D 1.51 (Predicted)
pK Values :
pKa: 14.28 (Predicted), pKb: -3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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