Date published: 2025-11-22

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2-(1,8-naphthyridin-2-yl)-Phenol (CAS 65182-56-1)

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Application:
2-(1,8-naphthyridin-2-yl)-Phenol is which selectively enhances STAT1 transcription activity
CAS Number:
65182-56-1
Purity:
≥98%
Molecular Weight:
222.24
Molecular Formula:
C14H10N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-(1,8-naphthyridin-2-yl)-Phenol is a cell-permeable naphthyridinyl-phenolic compound which selectively enhances cytokine-induced STAT1 transcription activity, but not STAT3 or NF-°B transcription activity. 2-(1,8-naphthyridin-2-yl)-Phenol is shown to prolong INF-g-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.


2-(1,8-naphthyridin-2-yl)-Phenol (CAS 65182-56-1) References

  1. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells.  |  Lynch, RA., et al. 2007. Cancer Res. 67: 1254-61. PMID: 17283162
  2. Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes.  |  Desmedt, C., et al. 2008. Clin Cancer Res. 14: 5158-65. PMID: 18698033
  3. Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets.  |  Walker, SR. and Frank, DA. 2012. JAKSTAT. 1: 292-9. PMID: 24058786
  4. Transfer hydrogenative para-selective aminoalkylation of aniline derivatives with N-heteroarenes via ruthenium/acid dual catalysis.  |  Chen, X., et al. 2018. Chem Commun (Camb). 54: 9087-9090. PMID: 30059076
  5. Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes.  |  Song, H., et al. 2019. J Immunol. 202: 2266-2275. PMID: 30842274
  6. miR-142-5p/DAX1-dependent regulation of P450c17 contributes to triclosan-mediated testosterone suppression.  |  Duan, P., et al. 2020. Sci Total Environ. 717: 137280. PMID: 32084696
  7. An enhanced chemopreventive effect of methyl donor S-adenosylmethionine in combination with 25-hydroxyvitamin D in blocking mammary tumor growth and metastasis.  |  Mahmood, N., et al. 2020. Bone Res. 8: 28. PMID: 32714613
  8. Cypermethrin triggers YY1-mediated testosterone biosynthesis suppression.  |  Liu, C., et al. 2021. Ecotoxicol Environ Saf. 225: 112792. PMID: 34544022
  9. Endogenous Follistatin-like 1 guarantees the immunomodulatory properties of mesenchymal stem cells during liver fibrotic therapy.  |  Zheng, X., et al. 2022. Stem Cell Res Ther. 13: 403. PMID: 35932064
  10. Friedländer reaction of 3-acetyltropolones: Synthesis of naphthyridinyl- and allied heterocyclic-substituted tropolones  |  Ming-Zhu Piao, Kimiaki Imafuku. 1996. Journal of Heterocyclic Chemistry. 33: 389-398.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-(1,8-naphthyridin-2-yl)-Phenol, 25 mg

sc-222326
25 mg
$298.00