Date published: 2026-3-19

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(1′S,2′S)-Nicotine 1′-Oxide and (1′R,2′S)-Nicotine 1′-Oxide Mixture (CAS 491-26-9)

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Application:
(1′S,2′S)-Nicotine 1′-Oxide and (1′R,2′S)-Nicotine 1′-Oxide Mixture is a nicotine derivative and human nicotine metabolite
CAS Number:
491-26-9
Molecular Weight:
178.23
Molecular Formula:
C10H14N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The (1′S,2′S)-Nicotine 1′-Oxide and (1′R,2′S)-Nicotine 1′-Oxide Mixture is a compound that functions as a potent agonist at nicotinic acetylcholine receptors. It acts by binding to these receptors and activating them, leading to the release of neurotransmitters such as dopamine, norepinephrine, and acetylcholine. This mixture of compounds may modulate synaptic transmission in the central nervous system, affecting cognitive function, mood, and behavior. At the molecular level, (1′S,2′S)-Nicotine 1′-Oxide and (1′R,2′S)-Nicotine 1′-Oxide Mixture exerts its effects by altering the flow of ions across the cell membrane, leading to changes in neuronal excitability and synaptic transmission. (1′S,2′S)-Nicotine 1′-Oxide And (1′R,2′S)-Nicotine 1′-Oxide Mixture′s mechanism of action may be for studying the role of nicotinic acetylcholine receptors in various physiological and pathological processes.


(1′S,2′S)-Nicotine 1′-Oxide and (1′R,2′S)-Nicotine 1′-Oxide Mixture (CAS 491-26-9) References

  1. A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry.  |  Miller, EI., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 725-37. PMID: 20097626
  2. Validation of a liquid chromatography-tandem mass spectrometry method for the detection of nicotine biomarkers in hair and an evaluation of wash procedures for removal of environmental nicotine.  |  Miller, EI., et al. 2011. J Anal Toxicol. 35: 321-32. PMID: 21740688
  3. Simultaneous quantification of nicotine and metabolites in rat brain by liquid chromatography-tandem mass spectrometry.  |  Vieira-Brock, PL., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 3465-74. PMID: 21963483
  4. Age-related differences in the disposition of nicotine and metabolites in rat brain and plasma.  |  Vieira-Brock, PL., et al. 2013. Nicotine Tob Res. 15: 1839-48. PMID: 23737496
  5. N-demethylation of nicotine and reduction of nicotine-1'-N-oxide by Microsporum gypseum.  |  Sindelar, RD., et al. 1979. Appl Environ Microbiol. 38: 836-9. PMID: 543700
  6. A reappraisal of the stereoselective metabolism of nicotine to nicotine-1'-N-oxide.  |  Testa, B., et al. 1976. Xenobiotica. 6: 553-6. PMID: 983125

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(1′S,2′S)-Nicotine 1′-Oxide and (1′R,2′S)-Nicotine 1′-Oxide Mixture, 10 mg

sc-213565
10 mg
$296.00