Date published: 2025-10-20

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(1′S,2′S)-Nicotine 1′-Oxide (CAS 51095-86-4)

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Alternate Names:
(1′S,2′S)-trans-Nicotine-1′-N-oxide
Application:
(1′S,2′S)-Nicotine 1′-Oxide is a stereoisomer of a natural Nicotine metabolite
CAS Number:
51095-86-4
Purity:
98%
Molecular Weight:
178.23
Molecular Formula:
C10H14N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(1′S,2′S)-Nicotine 1′-Oxide is a metabolite of nicotine that is of significant interest in the field of chemical research related to nicotine′s metabolic pathways. This compound is utilized to investigate the mechanisms of nicotine oxidation in the body, a process that contributes to understanding how nicotine is processed by living organisms. Research involving (1′S,2′S)-Nicotine 1′-Oxide often focuses on the role of specific enzymes, such as cytochrome P450s, in nicotine metabolism. It is also used in the study of potential biomarkers for nicotine exposure. Moreover, (1′S,2′S)-Nicotine 1′-Oxide is employed to explore the overall pharmacokinetics of nicotine, especially concerning the formation and clearance of its various metabolites.


(1′S,2′S)-Nicotine 1′-Oxide (CAS 51095-86-4) References

  1. Leveraging Uncertainty in Machine Learning Accelerates Biological Discovery and Design.  |  Hie, B., et al. 2020. Cell Syst. 11: 461-477.e9. PMID: 33065027
  2. Non-linear dose-response relation between urinary levels of nicotine and its metabolites and cognitive impairment among an elderly population in China.  |  Li, T., et al. 2021. Ecotoxicol Environ Saf. 224: 112706. PMID: 34461317
  3. N-demethylation of nicotine and reduction of nicotine-1'-N-oxide by Microsporum gypseum.  |  Sindelar, RD., et al. 1979. Appl Environ Microbiol. 38: 836-9. PMID: 543700

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(1′S,2′S)-Nicotine 1′-Oxide, 100 mg

sc-213564
100 mg
$400.00