Date published: 2026-5-31

1-800-457-3801

SCBT Portrait Logo
Seach Input

1β-Hydroxydeoxycholic Acid (CAS 80434-32-8)

0.0(0)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
1β,3α,12α-Trihydroxy-5β-cholan-24-oic Acid; 1β,3α,12α-Trihydroxy-5β-cholanoic Acid; (1β,3α,5β,12α)-1,3,12-Trihydroxycholan-24-oic Acid
CAS Number:
80434-32-8
Molecular Weight:
408.57
Molecular Formula:
C24H40O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

1β-Hydroxydeoxycholic Acid is a naturally occurring bile acid that is present in humans and other mammals. This compound is synthesized in the liver and stored in the gallbladder. Being a conjugated bile acid, it is connected to a sugar molecule, making it soluble in water. Its significance extends to its applications as a biomarker for liver injury. Moreover, it serves as a tool for investigating the impact of bile acids on physiological processes. Research has been conducted to explore its involvement in cholesterol and lipid metabolism, shedding light on its role in biochemical pathways.


1β-Hydroxydeoxycholic Acid (CAS 80434-32-8) References

  1. Fifty years with bile acids and steroids in health and disease.  |  Sjövall, J. 2004. Lipids. 39: 703-22. PMID: 15638239
  2. Novel pathways of bile acid metabolism involving CYP3A4.  |  Bodin, K., et al. 2005. Biochim Biophys Acta. 1687: 84-93. PMID: 15708356
  3. The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis.  |  Chen, J., et al. 2014. Ann Transl Med. 2: 7. PMID: 25332983
  4. CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity.  |  Hayes, MA., et al. 2016. Drug Metab Dispos. 44: 1480-9. PMID: 27402728
  5. Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis.  |  Batta, AK., et al. 1989. Hepatology. 10: 414-9. PMID: 2777202
  6. Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms.  |  Hayes, MA., et al. 2017. J Labelled Comp Radiopharm. 60: 221-229. PMID: 28183147
  7. Studies on the Unusual 1β-Hydroxylated Bile Acid Biosynthesis in Infants.  |  Nomura, Y., et al. 2018. Biol Pharm Bull. 41: 597-603. PMID: 29607932
  8. Phenotyping of Human CYP450 Enzymes by Endobiotics: Current Knowledge and Methodological Approaches.  |  Magliocco, G., et al. 2019. Clin Pharmacokinet. 58: 1373-1391. PMID: 31131437
  9. Structural Perspectives of the CYP3A Family and Their Small Molecule Modulators in Drug Metabolism.  |  Wright, WC., et al. 2019. Liver Res. 3: 132-142. PMID: 32789028
  10. Enzymatic Late-Stage Modifications: Better Late Than Never.  |  Romero, E., et al. 2021. Angew Chem Int Ed Engl. 60: 16824-16855. PMID: 33453143
  11. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs.  |  Wu, Q., et al. 2022. Drug Metab Dispos. 50: 741-749. PMID: 35351776
  12. The Role of CYP3A in Health and Disease.  |  Klyushova, LS., et al. 2022. Biomedicines. 10: PMID: 36359206
  13. Development of a Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analytical Method for Urinary Endogenous Substrates and Metabolites for Predicting Cytochrome P450 3A4 Activity.  |  Kumondai, M., et al. 2023. Biol Pharm Bull. 46: 455-463. PMID: 36858575

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1β-Hydroxydeoxycholic Acid, 2.5 mg

sc-490414
2.5 mg
$675.00