1α-Hydroxyvitamin D3 (CAS 41294-56-8)
See product citations (2)
QUICK LINKS
1alpha-Hydroxyvitamin D3 is a synthetic analog of Calcitiol (the hormonal form of vitamin D3), which shows identical potency with respect to stimulation of intestinal calcium absorption and bone mineral mobilization. It is a vitamin D source that has a high affinity for the vitamin D receptor (VDR) and is more potent than natural vitamin D. 1alpha-Hydroxyvitamin D3 binds to the VDR to form a complex, which then binds to vitamin D response elements (VDREs) in the promoter regions of vitamin D-responsive genes. This binding activates transcription of these genes, resulting in a variety of biological effects. These effects include the regulation of calcium and phosphate homeostasis, the stimulation of bone formation, and the modulation of immune responses. 1alpha-Hydroxyvitamin D3 also has anti-inflammatory and anti-cancer activities, and may act to have neuroprotective effects.
1α-Hydroxyvitamin D3 (CAS 41294-56-8) References
- Hypophosphataemic rickets. | Saggese, G. and Baroncelli, GI. 2000. Horm Res. 53 Suppl 3: 57-60. PMID: 10971106
- Cytochrome P450 enzymes in the bioactivation of vitamin D to its hormonal form (review). | Wikvall, K. 2001. Int J Mol Med. 7: 201-9. PMID: 11172626
- 1alpha-Hydroxyvitamin D3 suppresses trabecular bone resorption by inhibiting osteoclastogenic potential in bone marrow cells after ovariectomy in mice. | Sakai, A., et al. 2001. J Bone Miner Metab. 19: 277-86. PMID: 11498729
- Metabolic activation of 1alpha-hydroxyvitamin D3 in human liver microsomes. | Kamachi, S., et al. 2001. Xenobiotica. 31: 701-12. PMID: 11695849
- Metabolism of 1alpha-hydroxyvitamin D3 in the chick. | Holick, SA., et al. 1976. J Biol Chem. 251: 1025-8. PMID: 1249065
- Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3. | Tuckey, RC., et al. 2008. J Steroid Biochem Mol Biol. 112: 213-9. PMID: 19000766
- Direct C-1 hydroxylation of vitamin D compounds: convenient preparation of 1alpha-hydroxyvitamin D3, 1alpha, 25-dihydroxyvitamin D3, and 1alpha-hydroxyvitamin D2. | Paaren, HE., et al. 1978. Proc Natl Acad Sci U S A. 75: 2080-1. PMID: 209448
- Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice. | Chow, EC., et al. 2013. Biopharm Drug Dispos. 34: 402-16. PMID: 23897575
- Microbial production of 1α-hydroxyvitamin D3 from vitamin D3. | Ahmed, SA., et al. 2014. Nat Prod Res. 28: 444-8. PMID: 24456427
- Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. | Gu, X., et al. 2018. Exp Ther Med. 15: 2321-2326. PMID: 29456639
- The management of hypoparathyroidism with 1alpha-hydroxyvitamin D3. | Heyburn, PJ. and Peacock, M. 1977. Clin Endocrinol (Oxf). 7 Suppl: 209s-214s. PMID: 606418
- 1alpha-hydroxyvitamin D3 in primary hyperparathyroidism. | Boyle, IT., et al. 1977. Clin Endocrinol (Oxf). 7 Suppl: 215s-222s. PMID: 606419
- Human keratinocyte line HaCaT metabolizes 1alpha-hydroxyvitamin D3 and vitamin D3 to 1alpha,25-dihydroxyvitamin D3 (calcitriol). | Lehmann, B., et al. 1998. J Dermatol Sci. 18: 118-27. PMID: 9833978
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1α-Hydroxyvitamin D3, 1 mg | sc-220661 | 1 mg | $120.00 |