Molecular structure of 1α,25-Dihydroxyvitamin D2, CAS Number: 60133-18-8
1α,25-Dihydroxyvitamin D2 (CAS 60133-18-8)
See product citations (2)
Alternate Names:
Ercalcitriol
Application:
1α,25-Dihydroxyvitamin D2 is an active metabolite of vitamin D2
CAS Number:
60133-18-8
Purity:
≥96%
Molecular Weight:
428.65
Molecular Formula:
C28H44O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1alpha,25-Dihydroxyvitamin D2 is an active metabolite of vitamin D. It is known that 1alpha,25-Dihydroxyvitamin D2 can be detected in human serum using high-performance liquid chromatography and ultraviolet detection. Vitamin D2, known as ergocalciferol, is a fat soluble secosteroid which regulates neuromuscular function, reduces inflammation and controls cell proliferation, differentiation and apoptosis. Studies indicate that there are monoclonal antibodies that can test for the presence of 1alpha,25-Dihydroxyvitamin D2 via radioimmunoassays.
1α,25-Dihydroxyvitamin D2 (CAS 60133-18-8) References
- Biological activity profiles of 1alpha,25-dihydroxyvitamin D2, D3, D4, D7, and 24-epi-1alpha,25-dihydroxyvitamin D2. | Tsugawa, N., et al. 1999. Biol Pharm Bull. 22: 371-7. PMID: 10328556
- Physiological significance of C-28 hydroxylation in the metabolism of 1alpha,25-dihydroxyvitamin D(2). | Rao, DS., et al. 1999. Arch Biochem Biophys. 368: 319-28. PMID: 10441383
- Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2. | Masuda, S., et al. 2006. Biochim Biophys Acta. 1761: 221-34. PMID: 16516540
- Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1). | Nguyen, MN., et al. 2009. Drug Metab Dispos. 37: 761-7. PMID: 19116262
- A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3). | Mawer, EB., et al. 1990. Clin Chim Acta. 190: 199-209. PMID: 2253400
- In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. | Slominski, AT., et al. 2014. Mol Cell Endocrinol. 383: 181-92. PMID: 24382416
- Convergent synthesis of double point modified analogs of 1α,25-dihydroxyvitamin D2 for biological evaluation. | Nadkarni, S., et al. 2016. J Steroid Biochem Mol Biol. 164: 45-49. PMID: 26316152
- Synthesis and evaluation of geometric analogs of 1α,25-dihydroxyvitamin D2 as potential therapeutics. | Bolla, NR., et al. 2016. J Steroid Biochem Mol Biol. 164: 50-55. PMID: 26321387
- The Effect of Analogues of 1α,25-Dihydroxyvitamin D₂ on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil. | Neska, J., et al. 2016. Int J Mol Sci. 17: PMID: 27314328
- In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme. | Żołek, T., et al. 2022. Int J Mol Sci. 23: PMID: 35887195
- Gross and separative determination of 1 alpha,25-dihydroxyvitamin D2 and D3 in plasma using calf thymus receptor. | Masuda, S., et al. 1993. J Nutr Sci Vitaminol (Tokyo). 39: 101-14. PMID: 8410371
- Synthesis and biological activity of a 1 alpha,25-dihydroxyvitamin D2 analog bearing an amide group in the side-chain. | Konno, K., et al. 1997. Chem Pharm Bull (Tokyo). 45: 185-8. PMID: 9023979
- Pharmacokinetics and systemic effect on calcium homeostasis of 1 alpha,24-dihydroxyvitamin D2 in rats. Comparison with 1 alpha,25-dihydroxyvitamin D2, calcitriol, and calcipotriol. | Knutson, JC., et al. 1997. Biochem Pharmacol. 53: 829-37. PMID: 9113104
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1α,25-Dihydroxyvitamin D2, 1 mg | sc-224986 | 1 mg | $178.00 | |||
1α,25-Dihydroxyvitamin D2, 5 mg | sc-224986A | 5 mg | $679.00 | |||
1α,25-Dihydroxyvitamin D2, 10 mg | sc-224986B | 10 mg | $1215.00 | |||
1α,25-Dihydroxyvitamin D2, 25 mg | sc-224986C | 25 mg | $2556.00 |