1a,1b-dihomo Prostaglandin E1
Molecular Weight:
382.5
Molecular Formula:
C22H38O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, neonatal cardiology and erectile dysfunction(1,2). COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans(3). In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 were found to be much less active than PGE1 itself(4).
1a,1b-dihomo Prostaglandin E1 References
1 Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991). 2 Hoshi, K. Approved indications of lipo-PGE1 in Japan. Advanced Drug Delivery Reviews 20 171-176 (1996). 3 Samel, N., Maxey, K.M. Personal Communication. (2003). 4 Kloeze, J. Relationship between chemical structure and platelet-aggregation activity of prostaglandins. Biochim Biophys Acta 187 285-292 (1969).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1a,1b-dihomo Prostaglandin E1, 1 mg | sc-223191 | 1 mg | $60.00 | |||
1a,1b-dihomo Prostaglandin E1, 5 mg | sc-223191A | 5 mg | $270.00 |