Molecular structure of 19(R)-Hydroxy-prostaglandin E2, CAS Number: 64625-54-3
19(R)-Hydroxy-prostaglandin E2 (CAS 64625-54-3)
See product citations (2)
Alternate Names:
19(R)-hydroxy PGE2; 19(R)-OH PGE2
Application:
19(R)-Hydroxy-prostaglandin E2 is a PGE2 metabolite that acts as a selective EP2 receptor agonist
CAS Number:
64625-54-3
Purity:
>98%
Molecular Weight:
368.5
Molecular Formula:
C20H32O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
19(R)-Hydroxy-prostaglandin E2 is a PGE2 (sc-201225) metabolite that acts as a potent smooth muscle relaxant and a selective EP2 receptor agonist, contrary to PGE2, which can activate a variety of prostanoid receptor types. Reportedly, this compound occurs at significant levels in human seminal vesicles, but levels may vary across individuals possibly due to polymorphic expression of prostaglandin enzymatic mechanisms. It was found that microsomes of seminal vesicles metabolize exogenous prostaglandin E2 into 19(R)-Hydroxy-prostaglandin E2. This product was observed to activate plasma membrane A cyclase (adenylyl cyclase) and hepatocyte glycogen phosphorylase in isolated rockfish, but did not stimulate an FP-receptor preparation like PGE2.
19(R)-Hydroxy-prostaglandin E2 (CAS 64625-54-3) References
- Direct activation of rat spinal dorsal horn neurons by prostaglandin E2. | Baba, H., et al. 2001. J Neurosci. 21: 1750-6. PMID: 11222664
- Prostanoids stimulate K secretion and Cl secretion in guinea pig distal colon via distinct pathways. | Halm, DR. and Halm, ST. 2001. Am J Physiol Gastrointest Liver Physiol. 281: G984-96. PMID: 11557519
- Novel role for prostaglandin E2 in fish hepatocytes: regulation of glucose metabolism. | Busby, ER., et al. 2002. J Endocrinol. 174: 137-46. PMID: 12098672
- Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | Niedernberg, A., et al. 2003. Cell Signal. 15: 435-46. PMID: 12618218
- Functional pharmacology of human prostanoid EP2 and EP4 receptors. | Wilson, RJ., et al. 2004. Eur J Pharmacol. 501: 49-58. PMID: 15464062
- Prostaglandins E(2) and F(2alpha) enhance differentiation of cementoblastic cells. | Camargo, PM., et al. 2005. J Periodontol. 76: 303-9. PMID: 15974857
- High-performance liquid chromatography-thermospray mass spectrometry of prostaglandin and thromboxane acetyl derivatives. | Yamane, M. and Abe, A. 1991. J Chromatogr. 568: 11-24. PMID: 1770089
- Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. | Darios, F., et al. 2009. Neuron. 62: 683-94. PMID: 19524527
- Isolation and biosynthesis of 20-hydroxyprostaglandins E1 and E2 in ram seminal fluid. | Oliw, EH., et al. 1986. J Biol Chem. 261: 9216-21. PMID: 3087990
- Metagenomic-Metabolomic Mining of Kinema, a Naturally Fermented Soybean Food of the Eastern Himalayas. | Kharnaior, P. and Tamang, JP. 2022. Front Microbiol. 13: 868383. PMID: 35572705
- 19-Hydroxylated E prostaglandins as the major prostaglandins of human semen. | Taylor, PL. and Kelly, RW. 1974. Nature. 250: 665-7. PMID: 4855446
- Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist. | Woodward, DF., et al. 1993. Prostaglandins. 46: 371-83. PMID: 8248550
- Arachidonic acid 15-lipoxygenase and traces of E prostaglandins in purified human prostasomes. | Oliw, EH., et al. 1993. J Reprod Fertil. 99: 195-9. PMID: 8283438
Activator of:
A cyclase, and EP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
19(R)-Hydroxy-prostaglandin E2, 50 µg | sc-201252 | 50 µg | $101.00 | |||
19(R)-Hydroxy-prostaglandin E2, 1 mg | sc-201252A | 1 mg | $1300.00 |