Molecular structure of 19(R)-hydroxy Prostaglandin E1, CAS Number: 64625-55-4
19(R)-hydroxy Prostaglandin E1 (CAS 64625-55-4)
Alternate Names:
19(R)-hydroxy PGE1
Application:
19(R)-hydroxy Prostaglandin E1 is a potent Prostaglandin E1 metabolite and agonist for the EP1 and EP3 receptor subtypes
CAS Number:
64625-55-4
Purity:
>98%
Molecular Weight:
370.5
Molecular Formula:
C20H34O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
19(R)-hydroxy Prostaglandin E1 is the major prostaglandin found in the semen of primates, and is derived from PGE1 (sc-201223). This compound has been shown to be an agonist for the EP1 (320 nM) and EP3 (80 nM) receptor subtypes, which leads to contraction of smooth muscle. The fact that prostaglandin metabolites show biological effects different from their parent compounds illustrates one aspect of the complicated physiological functions of these diverse regulators. The use of prostaglandin analogues and metabolic derivatives is integral for structure-activity studies used in the deconvolution of these complex biochemical pathways.
19(R)-hydroxy Prostaglandin E1 (CAS 64625-55-4) References
- Prostaglandin concentrations in the semen of hypogonadal men during treatment with testosterone. | Skakkebaek, NE., et al. 1976. J Reprod Fertil. 47: 119-21. PMID: 1271361
- Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines. | Zhu, Y., et al. 2014. Asian Pac J Cancer Prev. 15: 3219-26. PMID: 24815474
- A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase. | Ibrahim, AS., et al. 2015. J Lipid Res. 56: 599-611. PMID: 25598081
- Observations on the substrate specificity of prostaglandin hydroxylases of monkey seminal vesicles and sheep vesicular glands. | Oliw, EH. 1989. Biochim Biophys Acta. 1001: 107-10. PMID: 2912490
- The 8-isoprostaglandins: evidence for eight compounds in human semen. | Taylor, PL. 1979. Prostaglandins. 17: 259-67. PMID: 441435
- 19-Hydroxylated E prostaglandins as the major prostaglandins of human semen. | Taylor, PL. and Kelly, RW. 1974. Nature. 250: 665-7. PMID: 4855446
- Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist. | Woodward, DF., et al. 1993. Prostaglandins. 46: 371-83. PMID: 8248550
Activator of:
EP1, and EP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
19(R)-hydroxy Prostaglandin E1, 50 µg | sc-205069 | 50 µg | $90.00 | |||
19(R)-hydroxy Prostaglandin E1, 100 µg | sc-205069A | 100 µg | $172.00 |