19-Iodocholesterol 3-acetate (CAS 4561-90-4)

19-Iodocholesterol 3-acetate is a derivative of cholesterol that has been extensively investigated in scientific research, particularly in the fields of endocrinology, radiology, and molecular imaging. This compound is utilized as a radiolabeled tracer for studying cholesterol metabolism and adrenal gland function. Upon administration, 19-iodocholesterol 3-acetate is selectively taken up by the adrenal glands, where it undergoes conversion to 19-iodocholesterol, a substrate for cholesterol side-chain cleavage enzyme (CYP11A1). This enzyme catalyzes the conversion of cholesterol to pregnenolone, a precursor of steroid hormones such as cortisol, aldosterone, and adrenal androgens. Researchers utilize 19-iodocholesterol 3-acetate in molecular imaging studies, such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET), to visualize adrenal gland morphology and assess adrenal function in various physiological and pathological conditions. Additionally, this compound serves as a valuable tool in investigating the regulation of steroidogenesis and adrenal steroid hormone production. Furthermore, 19-iodocholesterol 3-acetate finds applications in research to study adrenal disorders, adrenal tumors, and adrenal hormone excess syndromes. Its importance in elucidating adrenal gland physiology and pathology underscores its significance as a research tool in endocrine and imaging studies.