Molecular structure of 17β-hydroxy Wortmannin, CAS Number: 58053-83-1
17β-hydroxy Wortmannin (CAS 58053-83-1)
Application:
17β-hydroxy Wortmannin is an inhibitor of recombinant PI 3-kinase and mTOR
CAS Number:
58053-83-1
Molecular Weight:
430.4
Molecular Formula:
C23H26O8
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
17β-hydroxy Wortmannin is an analog of wortmannin (sc-3505). It irreversibly binds PI 3-kinase and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17beta-hydroxy Wortmannin inhibits recombinant PI 3-kinase and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 muM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin (sc-3504). 17β-hydroxy Wortmannin is a water-soluble compound that acts as a potent and selective inhibitor of phosphatidylinositol-3-kinase (PI3K).
17β-hydroxy Wortmannin (CAS 58053-83-1) References
- Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models. | Zhu, T., et al. 2006. J Med Chem. 49: 1373-8. PMID: 16480272
- Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates. | Ayral-Kaloustian, S., et al. 2010. J Med Chem. 53: 452-9. PMID: 19928864
- Rift Valley fever virus strain MP-12 enters mammalian host cells via caveola-mediated endocytosis. | Harmon, B., et al. 2012. J Virol. 86: 12954-70. PMID: 22993156
- CD28 and CD3 have complementary roles in T-cell traction forces. | Bashour, KT., et al. 2014. Proc Natl Acad Sci U S A. 111: 2241-6. PMID: 24469820
- Chemical Compositions and Aroma Evaluation of Volatile Oil from the Industrial Cultivation Medium of Enterococcus faecalis. | Ono, T., et al. 2015. J Oleo Sci. 64: 1125-33. PMID: 26369592
- A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog. | Bernhardt, K., et al. 2016. PLoS Pathog. 12: e1005405. PMID: 26800049
- A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage. | Li, J., et al. 2022. NAR Genom Bioinform. 4: lqac065. PMID: 36110898
- Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes. | Thelen, M., et al. 1994. Proc Natl Acad Sci U S A. 91: 4960-4. PMID: 8197165
Inhibitor of:
PI 3-kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17β-hydroxy Wortmannin, 500 µg | sc-358740 | 500 µg | $94.00 | |||
17β-hydroxy Wortmannin, 1 mg | sc-358740A | 1 mg | $180.00 |