Date published: 2026-5-12

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17β-Estradiol 3-β-D-Glucuronide (CAS 15270-30-1)

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Alternate Names:
(17β)-17-Hydroxyestra-1,3,5(10)-trien-3-yl β-D-Glucopyranosiduronic Acid
CAS Number:
15270-30-1
Molecular Weight:
448.51
Molecular Formula:
C24H32O8
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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17β-Estradiol 3-β-D-Glucuronide (E2-3G) is a significant metabolite derived from 17β-estradiol (E2), the most potent estrogen in humans. 17β-Estradiol 3-β-D-Glucuronide represents a major circulating form of estradiol in the body and is formed by glucuronidation of E2 in the liver. It can be detected in various bodily fluids, including serum and urine. This metabolite, 17β-Estradiol 3-β-D-Glucuronide, is involved in multiple essential physiological processes such as reproductive function, bone metabolism, and cardiovascular. Researchers have utilized it to explore the effects of estrogens on the body and their contribution to the development of various diseases.It is believed that 17β-Estradiol 3-β-D-Glucuronide participates in the regulation of diverse physiological processes. It acts as a ligand for the estrogen receptor (ER) and influences the activity of other hormones such as progesterone, testosterone, and cortisol. Moreover, it is thought to be involved in the regulation of cell proliferation, differentiation, and gene expression.


17β-Estradiol 3-β-D-Glucuronide (CAS 15270-30-1) References

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  2. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).  |  Chen, ZS., et al. 2003. Mol Pharmacol. 63: 351-8. PMID: 12527806
  3. Determination of estrogens and their conjugates in water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry.  |  Isobe, T., et al. 2003. J Chromatogr A. 984: 195-202. PMID: 12564690
  4. Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types.  |  Bovee, TF., et al. 2004. J Steroid Biochem Mol Biol. 91: 99-109. PMID: 15276617
  5. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11).  |  Chen, ZS., et al. 2005. Mol Pharmacol. 67: 545-57. PMID: 15537867
  6. Distribution of estrogens, 17beta-estradiol and estrone, in Canadian municipal wastewater treatment plants.  |  Servos, MR., et al. 2005. Sci Total Environ. 336: 155-70. PMID: 15589256
  7. Enzymatic treatment of estrogens and estrogen glucuronide.  |  Tanaka, T., et al. 2009. J Environ Sci (China). 21: 731-5. PMID: 19803074
  8. Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent.  |  Manevski, N., et al. 2013. PLoS One. 8: e54767. PMID: 23372764
  9. Simultaneous quantification of estrogens, their precursors and conjugated metabolites in human breast cancer cells by LC-HRMS without derivatization.  |  Poschner, S., et al. 2017. J Pharm Biomed Anal. 138: 344-350. PMID: 28249239
  10. The Impacts of Genistein and Daidzein on Estrogen Conjugations in Human Breast Cancer Cells: A Targeted Metabolomics Approach.  |  Poschner, S., et al. 2017. Front Pharmacol. 8: 699. PMID: 29051735

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

17β-Estradiol 3-β-D-Glucuronide, 2.5 mg

sc-496802
2.5 mg
$439.00