17β-Estradiol-2,3,4-13C3 (CAS 1261254-48-1)

17β-Estradiol-2,3,4-13C3 is a stable isotope-labeled analog of the naturally occurring hormone estradiol, which is widely used in biochemical and environmental research. The compound is particularly valuable in mass spectrometry as an internal standard, allowing for precise quantification of estradiol levels in various biological samples through isotope dilution techniques. In molecular biology, it is employed to study estrogen receptor binding and the subsequent gene expression changes, providing insights into the mechanisms of hormone action at a cellular level. Researchers also use 17β-Estradiol-2,3,4-13C3 in metabolic studies to track the hormone′s biosynthesis and degradation pathways, as well as its distribution and bioaccumulation in the environment. Furthermore, the incorporation of carbon-13 isotopes aids in elucidating the environmental fate of estrogenic compounds, which is of great concern due to their potential endocrine-disrupting effects on wildlife and ecosystems.