Molecular structure of 17-trifluoromethylphenyl trinor Prostaglandin F2α, CAS Number: 221246-34-0
17-trifluoromethylphenyl trinor Prostaglandin F2α (CAS 221246-34-0)
Application:
17-trifluoromethylphenyl trinor Prostaglandin F2α is a strong luteolytic and abortifacient
CAS Number:
221246-34-0
Molecular Weight:
456.5
Molecular Formula:
C24H31O5F3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3 Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a strong luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol.4
17-trifluoromethylphenyl trinor Prostaglandin F2α (CAS 221246-34-0) References
- Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues. | deLong, MA., et al. 2000. Bioorg Med Chem Lett. 10: 1519-22. PMID: 10915040
- From PGF(2alpha)-isopropyl ester to latanoprost: a review of the development of xalatan: the Proctor Lecture. | Stjernschantz, JW. 2001. Invest Ophthalmol Vis Sci. 42: 1134-45. PMID: 11328719
- A rationale for lowering intraocular pressure in glaucoma. | Weinreb, RN. 2001. Surv Ophthalmol. 45 Suppl 4: S335-6. PMID: 11434935
- NK1 receptor antagonistic effect of 17-trifluoromethyl phenyl trinor prostaglandin F2α on the growth of human breast cancer cell line. | Mayuri, M., et al. 2022. Exp Mol Pathol. 127: 104817. PMID: 35901925
- Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. | Resul, B., et al. 1993. J Med Chem. 36: 243-8. PMID: 8423596
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17-trifluoromethylphenyl trinor Prostaglandin F2α, 1 mg | sc-205062 | 1 mg | $62.00 | |||
17-trifluoromethylphenyl trinor Prostaglandin F2α, 5 mg | sc-205062A | 5 mg | $284.00 |